A Live Single-Cell Reporter System Reveals Drug-Induced Plasticity of a Cancer Stem Cell-Like Population in Cholangiocarcinoma

Since dual expression of the core pluripotent factors SOX2/OCT4 has been shown to correlate with poor outcome in cholangiocarcinoma patients, researchers selected the SOX2/OCT4 activating short half-life GFP-based live reporter to study CSC dynamics at the single-cell level.