Newsletters

[Nature Immunology] Researchers identified stress-responsive protein arachidonate lipoxygenase-15 (ALOX15) is a critical component of mitochondrial antiviral innate immunity.

[Emerging Microbes & Infections] Investigators provided the first unequivocal evidence of human CNS involvement by detecting Sindbis virus RNA directly in the cerebrospinal fluid of four autochthonous patients presenting with acute neurological symptoms in south eastern Tuscany, Italy, July-August 2025.

[Nature Communications] Scientists showed that CD11c^lo monocyte-derived cells, the subset of lung cells that is most permissive for Mtb viability during chronic infection, express lower levels of interferon-gamma (IFNγ) signaling proteins, resulting in reduced responses to IFNγ compared to alveolar macrophages and CD11c^hi monocyte-derived cells.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers detailed the infection of intestinal epithelia by an endemic, low-pathogenic human coronavirus, human alphacoronavirus 229E, using patient-derived human intestinal enteroids from donors of various ages.

[Journal of Biomedical Science] The authors defined the cytokine landscape of human macrophages infected with all four DENV serotypes and reverse genetics DENV2 strains carrying NS1 mutations derived from the severe 2015 Taiwan outbreak.

[EBioMedicine] Investigators demonstrated the capacity of two non-adjuvanted subunit vaccines to induce long-lasting and protective immunity against SARS-CoV-2 variants in macaques.

[EBioMedicine] Scientists examined the impact of HCV infection on CD4⁺ T cell susceptibility to HIV-1 infection in vitro and reservoir persistence during ART in subjects with chronic HCV infection and uninfected controls and longitudinally in one ART-treated HCV⁺HIV⁺ individual who spontaneously resolved multiple episodes of HCV infection.

[NPJ Vaccines] Investigators characterized the immunogenicity and efficacy of a Matrix-M^®–adjuvanted nanoparticle protein vaccine containing recombinant H5 HA of A/American wigeon/South Carolina/22/000345-001/2021 virus (clade 2.3.4.4b, H5-MNP).

[mBio] Researchers performed systematic, side-by-side comparisons of African, Asian, and American Zika virus lineage infections using cerebral organoids derived from human embryonic stem cells, a relevant human model experimental system.

[Immunity] The authors review current understanding of the cells of the nasal mucosa at homeostasis and their responses during and following viral infection in mice and humans.

[Atea Pharmaceuticals, Inc.] Atea Pharmaceuticals, Inc. announced the initiation of a first-in-human Phase I clinical trial evaluating AT-587, for the treatment of hepatitis E virus infection.

[Cancer Cell] Researchers described a method leveraging somatic mitochondrial mutations to reconstruct clonal lineage relationships between cells in native human tissues.