Loss of Stress Sensor GADD45A Promotes Stem Cell Activity and Ferroptosis Resistance in LGR4/HOXA9-Dependent AML

Researchers defined GADD45A as a key downstream target of LGR4 oncogenic signaling and discover a regulatory role for GADD45A loss in promoting leukemia-initiating activity and oxidative resistance in LGR4/HOXA9-dependent AML, a poor prognosis subset of leukemia.