Chimeric Antigen Receptors of HBV Envelope Proteins Inhibit Hepatitis B Surface Antigen Secretion

Researchers developed multiple chimeric antigen receptors based on single-chain variable fragments, respectively, targeting HBV large and small envelope proteins. Their impacts on hepatitis B surface antigen secretion and HBV infection, and the underlying mechanisms, were extensively investigated using various cell culture models and HBV mouse models.