Novel Cellular Systems Unveil Mucosal Melanoma Initiating Cells and a Role for PI3K/Akt/mTOR Pathway in Mucosal Melanoma Fitness

Five novel cell lines were obtained from patient-derived biopsies of mucosal melanomas (MM) arising in the sino-nasal mucosa and designated as SN-MM1-5. The morphology, ultrastructure and melanocytic identity of SN-MM cell lines were validated by transmission electron microscopy and immunohistochemistry.