Lipid Nanoparticles Efficiently Deliver a Trimeric Spike-Encoded DNA Vaccine to Robustly Induce Anti-SARS-CoV-2 Immunity Superior to the mRNA Vaccine in Syrian Hamsters

Investigators reported that plasmid encoding a trimeric spike protein with lipid nanoparticle delivery (pTS/LNP), similar to those in Moderna’s COVID-19 vaccine, induced more effective humoral responses than naked pTS or pTS delivered via electroporation.