Fused in Sarcoma Regulates Glutamate Signaling and Oxidative Stress Response

By obtaining humanized fust-1 amyotrophic lateral sclerosis (ALS) mutations via CRISPR-CAS9, investigators generated a C. elegans ALS model. Homozygous fust-1 ALS mutant and fust-1 deletion animals are viable in C. elegans.