Multiomics Analyses Reveal DARS1-AS1/YBX1–Controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/Radioresistance

The authors identified a lncRNA DARS1-AS1–controlled posttranscriptional circuitry that promoted the malignant properties of GBM cells/GSCs. Depleting DARS1-AS1 inhibited the proliferation of GBM cells/GSCs and self-renewal of GSCs, prolonging survival in orthotopic GBM models.