ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding

Oral administration of acyl-CoA synthetase-1 (ACSL1) inhibitor triacsin-C in mice before acute-high-fat feeding normalized the inflammatory/foamy phenotype of the circulatory monocytes by suppressing FABP4 expression.