KK-LC-1 as a Therapeutic Target to Eliminate ALDH⁺ Stem Cells in Triple Negative Breast Cancer

Scientists showed that Kita-Kyushu lung cancer antigen-1 (KK-LC-1) determined the stemness of TNBC aldehyde dehydrogenase (ALDH)+ cells via binding with FAT1 and subsequently promoting its ubiquitination and degradation.