N6-Methyladenine-Mediated Aberrant Activation of the lncRNA SOX2OT-GLI1 Loop Promotes Non-Small-Cell Lung Cancer Stemness

Researchers investigated the molecular mechanism of non-canonical aberrant glioma-associated oncogene homolog (GLI1) upregulation. The sonic hedgehog (SHH) cascade was upregulated in stem spheres and chemo-resistant lung cancer cells and was accountable for drug resistance against multiple chemotherapy regimens.