Deficiency of the CD155-CD96 Immune Checkpoint Controls IL-9 Production in Giant Cell Arteritis

Researchers reported that patients with the autoimmune vasculitis giant cell arteritis (GCA) had a defective CD155-CD96 immune checkpoint. Macrophages from patients with GCA retained the checkpoint ligand CD155 in the endoplasmic reticulum, and failed to bring it to the cell surface.