A Self-Propagating C-Met-SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

The sialylated cancer IgG(SIA-cIgG)/c-Met/SOX2/SIA-cIgG signaling loop was highly active in stem-like cells from many epithelial cancers and was crucial for cancer stemness in vitro and in vivo.