Tyrosine Kinase SRC-Induced YAP1-KLF5 Module Regulates Cancer Stemness and Metastasis in Triple-Negative Breast Cancer

Researchers identified a YAP1 tyrosine phosphorylation-dependent YAP1-Kruppel-like factor 5 (KLF5) oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer.