PTBP1-Activated Co-Transcriptional Splicing Controls Epigenetic Status of Pluripotent Stem Cells

Researchers examined the role of the RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) in the process of spliceosomal intron excision using an acute depletion approach followed by the analysis of chromatin- and RNA Pol II-associated transcripts.