Cancer Stem Cell Antigen Nanodisc Cocktail Elicits Anti-Tumor Immune Responses in Melanoma

Scientists identified novel immunogenic peptide epitopes derived from CSC-associated Sox2 and Nanog, and synthesized synthetic high-density lipoprotein nanodisc vaccine formulated with Sox2, Nanog, and aldehyde dehydrogenase antigen peptides together with CpG, a Toll-like receptor 9 agonist.