Regulating Nrf2-GPx4 Axis by Bicyclol Can Prevent Ferroptosis in Carbon Tetrachloride-Induced Acute Liver Injury in Mice

Erastin-treated L-O2 hepatocytes were transfected with glutathione peroxidase 4 (GPx4) or nuclear factor erythroid 2-related factor 2 (Nrf2) siRNA to delineate the pathway of bicyclol against ferroptosis in vitro.