Blockade of p38 MAPK Overcomes AML Stem Cell Line KG1a Resistance to 5-Fluorouridine and the Impact on miRNA Profiling

Researchers targeted the survival pathway p38 MAPK, NF-κB and ROS generation in human chemoresistant AML stem cell line KG1a, susceptible to enhance cell sensitivity to the chemotherapy drug 5-Fluorouridine, compared to the chemosensitive AML cell line HL60.