Newsletters

[Breast Cancer Research] Scientists investigated whether DNA methylation profiling can be useful as a biomarker to identify tumors arising in ataxia-telangiectasia mutated pathogenic variant carriers, which may help for the management and optimal tailoring of therapies of these patients.

[Cell Death Discovery] Scientists highlighted ex.50.T as a novel therapeutical avenue for breast cancer and potentially other gremlin-1-dependent malignancies, offering insights into disrupting tumor microenvironment dynamics and enhancing cancer treatment strategies.

[Medicinal Research Reviews] The authors manifest overall information regarding the effects of phytoestrogen on TNBC, along with its related cellular and molecular pathways in different TNBC models.

[Atossa Therapeutics, Inc.] Atossa Therapeutics, Inc. announced its strategic decision to pursue a metastatic breast cancer indication for (Z)-endoxifen.

[Neuron] Through CRISPR interference screening in human-derived neurons, scientists identified receptor-type tyrosine-protein phosphatase S (PTPσ) as a strong modifier of poly-GR-mediated toxicity.

[Science Advances] To investigate the glioblastoma (GBM)-specific 3D genome organization and its heterogeneity, investigators conducted Hi-C experiments in 21 GBM samples from nine patients, along with three normal brain samples.

[Science Translational Medicine] The authors explored the role of the immune responsive gene 1/itaconate pathway in regulating microglial bioenergetics and inflammatory activation post-traumatic brain injury using a mouse controlled cortical impact model.

[Stem Cells] Scientists explored the application of alternative midbrain-hindbrain boundary-secreted fibroblast growth factor (FGF)-family members, FGF17, and FGF18, for ventral midbrain dopaminergic progenitor patterning.

[Science Advances] The authors used an in vitro human cerebral organoid model with multiomic analysis, integrating advanced microscopies and single-cell RNA sequencing, to monitor tissue oxygen tension during neural development.

[BMC Musculoskeletal Disorders] The roles of different endothelial cell (EC) subsets in fracture healing were observed using scRNA-seq. It was found that metaphyseal ECs (mpECs) did affect the repair and regeneration of fracture sites, and could up-regulate genes related to the Notch signaling, angiogenesis, and cell cycle.

[Journal of Molecular and Cellular Cardiology ] Ligation of the femoral artery was performed in nondiabetic and three months diabetic mice with endothelial cell-specific deletion of SHP-1.

[Lab On A Chip] A common unifying approach based on gravitational lumen patterning was presented to create non-uniform, living 3D and closed vascular lumens embedded in a collagen matrix and lined with endothelial cells, resulting in reproduction of the architecture of straight vessels, stenosis, bifurcations, aneurysms and tortuous vessels.