Organoid News Volume 5.36 | Sep 12 2024

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    2024-09-12 | ON 5.36


    Organoid News by STEMCELL Technologies
    Vol. 5.36 – 12 September, 2024
    TOP STORY

    DNA Microbeads for Spatio-Temporally Controlled Morphogen Release within Organoids

    Scientists introduced nanoengineered DNA microbeads with tissue-mimetic tunable stiffness for implementing spatiotemporally controlled morphogen gradients inside organoids at any point in their development.
    [Nature Nanotechnology]

    Full Article
    An ISSCR 2022 Innovation Showcase Webinar: How to Choose the Right Neural Cell Culture Model for Your Research Question, presented by Dr. Erin Knock. Click to Watch Now.
    PUBLICATIONSListed by the impact factor of the journal

    METTL16-SENP3-LTF Axis Confers Ferroptosis Resistance and Facilitates Tumorigenesis in Hepatocellular Carcinoma

    The roles of METTL16 on ferroptosis and hepatocellular carcinoma (HCC) development were investigated in multiple cell lines, human HCC organoids, subcutaneous xenografts, and MYC/Trp53−/− HCC model in hepatocyte-specific Mettl16 knockout and overexpression mice.
    [Journal of Hematology & Oncology]

    Full Article

    Compressible Hollow Microlasers in Organoids for High-Throughput and Real-Time Mechanical Screening

    Investigators introduced biocompatible and compressible hollow microlasers that realized all-optical assessment of cellular stress within organoids.
    [ACS Nano]

    AbstractGraphical Abstract

    Thyroid Cancer Risk Associated with Perfluoroalkyl Carboxylate Exposure: Assessment Using a Human Dermal Fibroblast-Derived Extracellular Matrix-Based Thyroid Cancer Organoid

    Scientists investigated the effects of low-dose, long-term exposure to perfluoroalkyl carboxylates on human thyroid cancer organoids to advance understandings of thyroid cancer pathology within the context of environmental health risks.
    [Journal of Hazardous Materials]

    Full ArticleGraphical Abstract

    Characterizing the Effects of Triclosan and Triclocarban on the Intestinal Epithelial Homeostasis Using Small Intestinal Organoids

    A novel 3D intestinal organoid model was utilized to investigate whether exposure to triclosan/triclocarban led to a compromised self-renewal and differentiation of intestinal stem cells.
    [Journal of Hazardous Materials]

    Full ArticleGraphical Abstract

    Brain Organoid Maturation and Implantation Integration Based on Electrical Signals Input

    Investigators found that electrical stimulation could promote the development of cortical organoids. Electric stimulation-pretreated organoids were better transplanted donors for strengthening connectivity between grafts and host.
    [Journal of Advanced Research]

    Full ArticleGraphical Abstract

    Influence of Mesenchymal and Biophysical Components on Distal Lung Organoid Differentiation

    Researchers investigated the contributions of cellular constituents of the alveolus and fetal respiratory movements on human PSC-derived alveolar organoid formation.
    [Stem Cell Research & Therapy]

    Full Article

    Endothelialized Bronchioalveolar Lung Organoids Model Endothelial Cell Responses to Injury

    Researchers described a novel method that adds another level of intricacy to bronchioalveolar lung organoid models by microinjection of FACS-sorted lung endothelial cells into differentiated organoid cultures.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract

    Modeling SARS-CoV-2 Infection in a Human Alveolus Microphysiological System

    Investigators described the adaptation of a human alveolus microphysiological system model consisting of primary human alveolar epithelial and lung microvascular endothelial cells to study infection with SARS-CoV-2 at a Biosafety Level 3 facility.
    [Access Microbiology]

    Full ArticlePress Release
    Learn how to be a great STEM mentor to new lab members
    REVIEWS

    Neural Tube Organoids: A Novel System to Study Developmental Timing

    The authors summarize current research using both mouse and human neural tube organoids and compares developmental timing events in order to assess if allochrony is maintained in organoids.
    [Stem Cell Reviews and Reports]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    FibroBiologics Announces Filing of Patent Application for Generation of Three-dimensional Organoids using Fibroblast Cell-Based Technology

    FibroBiologics, Inc. announced the filing of a patent application with the United States Patent Office covering the use of fibroblast cell-based technology in generating three-dimensional hemopoietic organoids that can give rise to immune cells.
    [Fibrobiologic, Inc.]

    Press Release
    FEATURED EVENT

    Cell & Gene Therapy Manufacturing & Commercialization Asia 2024

    October 21 – 23, 2024
    Kyoto, Japan

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    JOB OPPORTUNITIES

    Tenure Track Assistant Professor – Organoid Systems

    Technical University of Munich – Munich, Germany

    Assistant/Associate/Full/Chair Professor – Medicine

    Westlake University – Zhejiang, China

    Research Scientist – Tissue Regeneration and Clonal Evolution

    Francis Crick Institute – London, England, United Kingdom

    Postdoctoral Fellow – PSCs and Brain Organoids

    Emory University – Brookhaven, Georgia, United States

    Postdoctoral Fellow – Autism Spectrum Disorder

    Weill Cornell Medical College – New York City, New York, United States

    > See All Jobs

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