 | | Vol. 5.09 – 7 March, 2024 |
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| Using single-cell analysis, the authors characterized the cellular identities present in human amniotic fluid. They identified and isolated viable epithelial stem/progenitor cells of fetal gastrointestinal, renal, and pulmonary origin.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To understand this process in early colorectal cancers, scientists investigated how naive colon cancer organoids that were engineered in vitro to harbor Apc-null, KrasG12D and Trp53-null mutations adapted to the in vivo native colonic environment.
[Nature] |
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| Investigators demonstrated that induction of a gliogenic switch in a subset of progenitors enabled the rapid derivation of astroglial cells, which account for 25–31% of the cell population within 8–10 weeks of differentiation.
[Nature Biotechnology] |
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| Researchers discovered CDH1 inactivation in a subset of diffuse-type gastric adenocarcinoma (DGAC) patient tumors. Analyzing single-cell transcriptomes in malignant ascites, they identified two DGAC subtypes: DGAC1 (CDH1 loss) and DGAC2 (lacking immune response).
[Journal Of Experimental Medicine] |
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| The authors established a panel of colorectal cancer (CRC) patient-derived organoids (PDOs) as clinically relevant biological systems, of which three pairs of matched metastatic CRC PDOs were derived from the primary sites and metastatic lesions.
[npj Precision Oncology] |
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| Scientists established intestinal organoids from enterocyte-like cells generated using our protocol. Furthermore, monolayers were produced from the organoids.
[Stem Cell Research & Therapy] |
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| Investigators introduced an agarose microwell platform designed for patient-derived organoid-based tumor and tumor microenvironment models, enabling rapid drug screening and resistance studies with small sample volumes.
[Lab On A Chip] |
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| Researchers presented a thermoplastic-based microphysiological system aiming to model the complex microphysiological structure and function of the endocrine pancreas with concurrent real-time read-out capabilities.
[Lab On A Chip] |
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| Treatment with cinnamic acid led to upregulation of oxytocin receptor and trichogenic gene expression in human dermal papilla cells.
[Scientific Reports] |
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| The authors explore the potential of 2D or 3D culture models comprising hiPSCs and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance the understanding of human aging and to catalyze the discovery of anti-aging interventions.
[Nature Communications] |
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| Investigators provide an overview of the chip designs and culturing strategies employed for vascularized organoid-on-a-chip, as well as the applicable optical imaging and tissue optical clearing methods.
[Angiogenesis] |
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| Scientists have finally managed to put elephant skin cells into an embryonic state. The breakthrough — announced by the de-extinction company Colossal Biosciences in Dallas, Texas — is an early technical success in Colossal’s high-profile effort to engineer elephants with woolly mammoth traits.
[Nature] |
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| May 2 – 3, 2024
Helsingør, Denmark |
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| | University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | The Institute of Genetics, Molecular and Cellular Biology – Strasbourg-Ville, France |
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| | Luxembourg Centre for Systems Biomedicine – Esch-sur-Alzette, Luxembourg |
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| | Johns Hopkins Medicine Pathology – Baltimore, Maryland, United States |
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| | The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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