Organoid News Volume 4.03 | Jan 26 2023

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    2023-01-26 | ON 4.03


    Organoid News by STEMCELL Technologies
    Vol. 4.03 – 26 January, 2023
    TOP STORY

    In Vivo Development of Immune Tissue in Human Intestinal Organoids Transplanted into Humanized Mice

    To decipher human intestinal–immune crosstalk during development, scientists generated human intestinal organoids (HIOs) containing immune cells by transplanting HIOs under the kidney capsule of mice with a humanized immune system.
    [Nature Biotechnology]

    Full ArticlePress Release

    Scientific resources to support your organoids research. Learn More!
    PUBLICATIONSRanked by the impact factor of the journal

    Antibody-Exatecan Conjugates with a Novel Self-Immolative Moiety Overcome Resistance in Colon and Lung Cancer

    The authors designed an antibody-drug conjugates class using a novel self-immolative T moiety for traceless conjugation and release of exatecan, a more potent Topoisomerase I inhibitor with less sensitivity to multidrug resistance.
    [Cancer Discovery]

    Abstract

    Preclinical Patient-Derived Modeling of Castration-Resistant Prostate Cancer Facilitates Individualized Assessment of Homologous Recombination Repair Deficient Disease

    In vitro, castration-resistant prostate cancer (LNCaP) sublines revealed a homologous recombination repair defect and enhanced sensitivity to olaparib and cisplatin due to impaired RAD51 expression and recruitment.
    [Molecular Oncology]

    Abstract

    Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical Potential

    Preclinical models with human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes, epicardial cells, and kidney organoids were used to investigate toxicity risks of tumor-specific T cells more thoroughly.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

    CDK1 Bridges NF-κB and β-Catenin Signaling in Response to H. pylori Infection in Gastric Tumorigenesis

    CDK1 phosphorylated and inhibited GSK-3β activity through direct binding with subsequent accumulation and activation of β-catenin. CDK1 silencing or pharmacologic inhibition reversed these effects and impairs tumor organoids and spheroid formation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    USP7 Inactivation Suppresses APC-Mutant Intestinal Hyperproliferation and Tumor Development

    Scientists showed in vivo that deletion of Usp7 in Apc-truncated mice inhibits crypt hyperproliferation and intestinal tumor development.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    The Crosstalk between Microbial Sensors ELMO1 and NOD2 Shape Intestinal Immune Responses

    The authors studied whether nucleotide-binding oligomerization domain-containing protein 2 (NOD2) and engulfment and cell motility protein-1 (ELMO1) interacted with each other directly or indirectly to regulate bacterial sensing.
    [Virulence]

    Full Article

    Discovery of AXL Degraders with Improved Potencies in Triple-Negative Breast Cancer (TNBC) Cells

    Investigators reported the discovery of a series of new AXL PROTAC degraders. One representative compound 6n potently depleted AXL with a DC50 value of 5 nM in MDA-MB-231 TNBC cells.
    [European Journal Of Medicinal Chemistry]

    AbstractGraphical Abstract
    Learn more about HepatiCult Organoid Growth Medium (Mouse)
    REVIEWS

    Towards a Better Understanding of Diabetes Mellitus Using Organoid Models

    The authors review organoid models for studying diabetes mellitus and provide insights into development, hormones and glucose toxicity effects in the pancreas and other organs.
    [Nature Reviews Endocrinology]

    Full Article

    Bone/Cartilage Organoid On-Chip: Construction Strategy and Application

    Scientists propose the concept of bone/cartilage organoid on-chip platform, and summarize the basic modules and current efforts to orchestrate them on a single microfluidic system.
    [Bioactive Materials]

    Full Article

    Kidney Disease and Viral Infection in COVID-19: Why Are Kidney Organoid and Biopsy Studies Not in Agreement?

    Kidney organoids derived from human ESCs or induced pluripotent cells could be reproducibly infected by SARS-CoV-2 in vitro and used to study therapeutics. However, kidney biopsy studies of COVID-19 patients with renal dysfunction have shown no evidence of viral infection.
    [Nephron]

    Press Release
    INDUSTRY AND POLICY NEWS

    ERC Proof of Concept Grant for Mina Gouti

    Organoids have to be fed and cared for continuously so that they can mature. So far, it is mostly a manual process – not suitable for industrial drug screening. Now, the European Research Council (ERC) has awarded Mina Gouti a Proof of Concept Grant to tackle scalability and reproducibility.
    [Max Delbrück Center]

    Press Release
    FEATURED EVENT

    3D Cell Culture 2023: Models, Applications & Translation

    April 17 – 19, 2023
    Freiburg im Breisgau, Germany

    > See All Events

    JOB OPPORTUNITIES

    PhD Scholarships – Organ Bioprinting

    National University of Ireland Galway – Galway, Ireland

    Postdoctoral Research Fellow – Liver Organoids

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Research Associate – Organoid Models of Development and Repair

    The University of Cambridge – Cambridge, England, United Kingdom

    PhD Position – Organoid-Based Biotechnology

    Masaryk University – Brno, Czech Republic

    Postdoctoral Scientist – Cell Biology

    MRC National Institute for Medical Research – Cambridge, England, United Kingdom

    > See All Jobs

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