Organoid News Volume 3.37 | Sep 22 2022

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    2022-09-22 | ON 3.37


    Organoid News by STEMCELL Technologies
    Vol. 3.37 – 22 September, 2022
    TOP STORY

    Single-Cell Atlas of Human Liver Development Reveals Pathways Directing Hepatic Cell Fates

    Scientists addressed the lack of knowledge concerning human hepatic development by describing the developmental trajectories of different cell types that make up the human liver at single-cell resolution.
    [Nature Cell Biology]

    Abstract
    2nd iPSC-Derived Cell Therapies Summit: The Flagship Forum Showcasing Discovery, Translation, CMC and Regulatory Advances
    PUBLICATIONSRanked by the impact factor of the journal

    Organoid-on-a-Chip Model of Human ARPKD Reveals Mechanosensing Pathomechanisms for Drug Discovery

    Researchers united organoids with organ-on-a-chip technology to unravel disease pathology and develop therapies for autosomal recessive polycystic kidney disease.
    [Science Advances]

    Full ArticlePress Release

    Optogenetic Control of Apical Constriction Induces Synthetic Morphogenesis in Mammalian Tissues

    Investigators reported the development of OptoShroom3, an optogenetic tool that achieved fast spatiotemporal control of apical constriction in mammalian epithelia.
    [Nature Communications]

    Full Article

    Colorectal Cancer Organoid Models Uncover Oxaliplatin-Resistant Mechanisms at Single Cell Resolution

    The authors established two strains of patient-derived organoids (PDOs) selected from oxaliplatin-resistant and treatment-naïve CRC patients. To dissect the drug-resistant mechanisms, these colorectal cancer-PDOs were subjected to single-cell RNA sequencing.
    [Cellular Oncology]

    Abstract

    SARS-CoV-2 Infection of Human Pluripotent Stem Cell-Derived Liver Organoids Reveals Potential Mechanisms of Liver Pathology

    Scientists used human induced pluripotent stem cell-derived liver organoids to recapitulate and characterize liver pathology following virus exposure.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms

    Researchers identified fibroblast growth factor signaling in feeder-free PSC maintenance as a key factor that determines the differentiation toward cerebral organoids.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    In-Depth Analysis of the Relationship Between Bovine Intestinal Organoids and Enteroids Based on Morphology and Transcriptome

    “Natural” organoids were obtained by tissue culture from fetal bovine jejunum and enteroids were successfully isolated and cultured from organoids without supplementing exogenous factors and Matrigel.
    [Tissue Engineering and Regenerative Medicine]

    Abstract

    Deep-Learning Analysis of Micropattern-Based Organoids Enables High-Throughput Drug Screening of Huntington’s Disease Models

    Investigators presented a method that overcomes the reproducibility and scalability limitations of organoids by using deep-learning-driven analysis for phenotypic drug screens based on highly standardized micropattern-based neural organoids.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract
    Webinar: Advances in Human Brain Organoid Models
    REVIEWS

    From Organoids to Bedside: Advances in Modeling, Decoding and Targeting of Colorectal Cancer

    Investigators review the role of organoids to decode cancer cell dynamics and tumor microenvironmental complexity with the underlying bi-directional crosstalk.
    [International Journal of Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Maryland Stem Cell Research Fund Launches Stem Cell Therapy Manufacturing Grant Program

    A program that supports young stem cell companies is launching a new funding opportunity to increase cell therapy manufacturing capacity in Maryland after seeing its state funding more than double.
    [MarylandInno]

    Press Release
    FEATURED EVENT

    16th International Symposium on Dendritic Cells 2022

    October 9 – 13, 2022
    Cairns, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Stem Cell Organoids

    Syracuse University – Syracuse, New York, United States

    Assistant Professor – Stem Cell Biology

    University of California Santa Cruz – Santa Cruz, California, United States

    Research Technician – 3DVasCMD

    European Molecular Biology Laboratory – Barcelona, Spain

    PhD Fellowship – Gene Therapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Postdoctoral/Research Scientist – CRISPR/Cas Genome Editors

    Lewis Katz School of Medicine, Temple University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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