 | | Vol. 3.34 – 1 September, 2022 |
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| In a 3D matrix, the spheres form ureteric bud (UB) organoids that exhibited branching morphogenesis similar to the fetal UB and correct distal tip localization of RET expression.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists optimized human small intestinal organoid culturing, constitutively generating all differentiated cell types while maintaining an active stem cell compartment.
[Cell Stem Cell] |
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| Investigators elucidated the molecular hallmarks and therapeutically actionable features of patients with resistance to CDK4/6 inhibitors.
[Molecular Cancer] |
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| Murine intestinal and pulmonary organoids were harnessed to demonstrate that the epithelial niche was sufficient to drive tissue-specific maturation of all innate lymphoid cell groups in parallel, without requiring subset-specific cytokine supplementation.
[Cell Reports] |
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| Spheroids were expanded into organoids that possessed NKX2-1+/CPM+ bud tip progenitors-like cells, which increased in number over time.
[Development] |
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| Researchers detailed a method for cryobanking of epithelial cells from either mouse or human lung tissue for preservation of their phenotypic and functional characteristics.
[American Journal of Respiratory Cell and Molecular Biology] |
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| Scientists used immunohistochemistry, gene expression analysis, and organoid culture to evaluate the effect of black raspberries on intestinal homeostasis.
[Molecular Nutrition & Food Research] |
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| Researchers investigated the direct effects of three inflammatory cytokines, TNFα, IFNγ, and IL-18, on the bovine intestinal barrier utilizing intestinal organoids.
[Scientific Reports] |
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| The authors found that the histological characteristics of organoids were consistent with original lesions and recapitulated their heterogenicity. In addition, the next-generation sequencing results showed that PIK3CA and TP53 genes had detrimental mutations.
[Journal of Oncology] |
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| Scientists review the recent developments in the use of 3D liver organoids as a model to study nonalcoholic fatty liver disease and nonalcoholic steatohepatitis pathophysiology and possible treatments.
[Seminars in Liver Disease] |
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| Investigators summarize the status of rodent retinal degeneration disease models and discuss retinal organoids (ROs) culture and analytical tools to evaluate RO quality and function.
[Asia-Pacific Journal of Clinical Oncology] |
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| A complex mix of politics, economics and shifting career priorities has made it hard for principal investigators to recruit new lab members.
[Nature News] |
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| October 24 – 26, 2022
Madrid, Spain |
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| | Radboud University Medical Center – Nijmege, The Netherlands |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | STEMCELL Technologies, Inc. – Vancouver, British Columbia, Canada |
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| | Yale University – New Haven, Connecticut, United States |
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