 | | Vol. 2.02 – 21 January, 2021 |
| |
|
|
| CRISPR/Cas9-mediated ARID1A knockout in primary TP53-/- human gastric organoids induced morphologic dysplasia, tumorigenicity and mucinous differentiation.
[Cancer Discovery] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Mouse lineage tracing, organoid culture and single-molecule RNA in situ hybridizations revealed that the two epithelia derived from separate cervix-resident lineage-specific stem cell populations regulated by opposing Wnt signals from the stroma.
[Nature Cell Biology] |
|
|
|
| The authors report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of Alzheimer’s disease with human induced pluripotent stem cell-derived cerebral organoids, including CRISPR-Cas9-edited isogenic lines.
[Nature Communications] |
|
|
|
| Scientists showed that inhibition of PHGDH, the first step in the serine synthesis pathway, cooperated with serine and glycine depletion to inhibit one-carbon metabolism and cancer growth.
[Nature Communications] |
|
|
|
| Researchers purified different cochlear cell types from neonatal mice, validated the composition of the different groups with single-cell RNA sequencing, and assessed the various groups’ potential to grow into inner ear organoids.
[Cell Reports] |
|
|
|
| Investigators demonstrated the use of human small intestinal organoids to model ischemia-reperfusion injury by exposing organoids to hypoxia and reoxygenation.
[Cell Death & Disease] |
|
|
|
| Researchers investigated the expression of insulin growth factor binding proteins and their role in the generation of human retinal organoids from human pluripotent stem cells.
[Stem Cells] |
|
|
|
| Scientists provided automated protocols for neuronal differentiation of neural progenitor cells in 2D culture and 3D midbrain organoids for high throughput screenings.
[Scientific Reports] |
|
|
|
| The authors describe and characterized a protocol focused on the generation of retinal ganglion cells within an accelerated four week timeframe without any external small molecules or growth factors.
[Scientific Reports] |
|
|
|
|
| Scientists summarize existing data on the replication of SARS-CoV-2 in different tissues in both patients and ex vivo models.
[Clinical Microbiology Reviews] |
|
|
|
| The authors review recent advances in the development of CNS organoid models, their application in neurodegenerative diseases and technical limitations.
[Tissue Engineering Part C: Methods] |
|
|
|
|
| RheinCell Therapeutics GmbH announced it has received Good Manufacturing Practice certification and Manufacturing Authorization. This marks a landmark achievement for RheinCell, which is now among a select few iPSCs manufacturers to have received the critical certification.
[Lifescience Newswire] |
|
|
|
|
|
|
|
| | Queen Mary University of London – London, England, United Kingdom |
|
|
|
| | Cedars-Sinai – Los Angeles, California, United States |
|
|
|
| | University of Luxembourg – Luxembourg City, Luxembourg |
|
|
|
| | University of Luxembourg – Belval, Luxembourg |
|
|
|
| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
