Organoid News Volume 5.20 | May 23 2024

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    2024-05-23 | ON 5.20


    Organoid News by STEMCELL Technologies
    Vol. 15.20 – 23 May, 2024
    TOP STORY

    Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis

    A new method to produce kidney organoids with vascular-like structures was achieved through the assembly of hPSC-derived endothelial-like organoids with kidney organoids in 3D.
    [Advanced Materials]

    Abstract
    Grow Intestinal Organoids from hPSCs With STEMdiff™ Intestinal Organoid Kit
    PUBLICATIONSRanked by the impact factor of the journal

    Breast Cancer-on-Chip for Patient-Specific Efficacy and Safety Testing of CAR-T Cells

    Researchers developed a breast cancer-on-chip model with an integrated endothelial barrier that enables the transmigration of perfused immune cells, their infiltration into the tumor, and concomitant monitoring of cytokine release during perfused culture over a period of up to eight days.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Biomimetic Hydrogels with Mesoscale Collagen Architecture for Patient-Derived Tumor Organoids Culture

    Investigators presented a rapid technique for generating collagen bundles with an average length of 90 ± 27 μm and a mean diameter of 5 ± 1.5 μm from tumor tissue debris that underwent mechanical agitation following enzymatic digestion.
    [Bioactive Materials]

    Full ArticlePress Release

    Mouse Neural Tube Organoids Self-Organize Floorplate through BMP-Mediated Cluster Competition

    Scientists investigated floorplate self-organization in clonal mouse neural tube organoids. Expression of the floorplate marker FOXA2 was initially spatially scattered before resolving into multiple clusters, which underwent competition and sorting, resulting in a stable “winning” floorplate.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    hiPSC-Derived Macrophages Improve Drug Sensitivity and Selectivity in a Macrophage-Incorporating Organoid Culture Model

    Researchers created macrophage-containing organoid co-culture models by directly incorporating hiPSC-derived pre-macrophages into organoid and scaffold cell models.
    [Biofabrication]

    Abstract

    Trans-Omic Profiling Uncovers Molecular Controls of Early Human Cerebral Organoid Formation

    To elucidate the molecular programs that drive human brain formation, investigators generated a comprehensive trans-omic map of the phosphoproteome, proteome, and transcriptome of the exit of pluripotency and neural differentiation toward human cerebral organoids.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Reproducible Generation of Human Liver Organoids (HLOs) on a Pillar Plate Platform via Microarray 3D Bioprinting

    Microarray 3D bioprinting, a droplet-based printing technology, was used to generate a large number of small organoids on the pillar plate for predictive hepatotoxicity assays.
    [Lab On A Chip]

    AbstractGraphical Abstract

    Human Pluripotent Stem Cell-Derived Kidney Organoids Reveal Tubular Epithelial Pathobiology of Heterozygous HNF1B-Associated Dysplastic Kidney Malformations

    Investigators generated heterozygous hepatocyte nuclear factor 1B (HNF1B) mutant kidney organoids from CRISPR-Cas9 gene-edited human ESCs and induced PSCs reprogrammed from a family with HNF1B-associated dysplastic kidney malformations.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Transmissible Gastroenteritis Virus Induces Inflammatory Responses via RIG-I/NF-κB/HIF-1α/Glycolysis Axis in Intestinal Organoids and In Vivo

    The authors found that apical-out organoids were susceptible to transmissible gastroenteritis virus infection (TGEV), and the expression of representative inflammatory cytokines was significantly upregulated upon TGEV infection.
    [Journal of Virology]

    Abstract
    Reliably Generate Spheroids with AggreWell™
    REVIEWS

    Organoid Bioinks: Construction and Application

    Scientists provide a rigorous, focused examination of the evolution and impact of organoid bioprinting. It emphasizes the role of organoid bioinks that integrate key cellular components and microenvironmental cues to more accurately replicate native tissue complexity.
    [Biofabrication]

    Full Article

    Rigor and Reproducibility in Human Brain Organoid Research: Where We Are and Where We Need to Go

    Investigators review current analytical platforms used to characterize human forebrain cortical organoids, highlight challenges, and propose recommendations for future studies to achieve greater precision and uniformity across laboratories.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    City of Hope Awarded $5.4 Million CIRM Grant to Create a Stem Cell Laboratory and Expand Access to State-of-the-Art Disease Models and Technology Among a Diverse Scientific Community

    City of Hope has been awarded $5.4 million from the California Institute for Regenerative Medicine (CIRM) to build and fund a stem cell research laboratory on its Duarte, California, campus that will further expand its scientific capabilities.
    [City of Hope]

    Press Release

    T. Boone Pickens’ Posthumous Donation to Fund ‘Organoid’ Research Among Other Hotchkiss Brain Institute Programs

    A legacy gift to a specialized center at the University of Calgary’s Cumming School of Medicine will fund emerging research that includes creating miniature-brain-like cells, called “organoids.”
    [CTV News]

    Full Article
    FEATURED EVENT

    AMP Europe 2024

    June 24 – 26, 2024
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Technician – ER+ Breast Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Research Technician – Cancer Biology

    Virginia Tech – Blacksburg, Virginia, United States

    Postdoctoral Scholarship – Immune-Competent Organoids of Brain Disease

    University of Antwerp – Antwerp, Belgium

    Postdoctoral Scientist – Neuroimmune Organoid Platform for Dementia

    VIB – Ghent, Belgium

    Postdoctoral Researcher – Brain Organoids Technologies

    University of Luxembourg – Esch-sur-Alzette, Luxembourg

    > See All Jobs

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