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Pulmonary Cell News| Mesenchymal Cell News 10.40 October 9, 2018 | |
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TOP STORYLarge variations were observed in proangiogenic factor secretion profiles of conditioned media derived from nine different donor-derived Wharton’s jelly (WJ)-derived MSCs and eight factors among 55 angiogenesis-related factors were secreted at considerable levels. Two distinct WJ-MSCs that had the lowest or the highest secretion of these eight factors showed corresponding proangiogenic activities in in vitro angiogenesis assays. [Stem Cells] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROResearchers utilized GeNorm for downstream qRT-PCR applications, the stability of reference genes in relation to optimal cDNA amounts was assessed on human bone marrow-derived mesenchymal and adipose-derived stem cells neat and made to differentiate into chondrocytes including normal human derived chondrocytes and muscle tissue from rats. [Sci Rep] Full Article Osteoblastogenesis-related marker genes expression including osteorix, osteocalcin, and runx2 were increased after BMSC were treated with HAp-1 for six days. Although three kinds of HAps treatment for nine days increased osteorix mRNA expression, osteocalcin, and runx2 mRNA expression levels were upregulated only by HAp-1. [J Biomed Mater Res A] Abstract Investigators showed that exposure to ionic dissolution products from 1393 and 45S5 bioactive glasses (BAGs) could evoke distinct angiogenic and osteogenic responses from primary MSCs in a dose- and composition-dependent manner. Significantly higher concentrations of the pro-angiogenic factors VEGF, HGF, PIGF, angiopoietin, and angiogenin were detected in conditioned media from MSCs exposed to 45S5, but not 1393, BAGs. [J Biomed Mater Res A] Abstract IN VIVOBMSCs Pre-Treatment Ameliorates Inflammation-Related Tissue Destruction in LPS-Induced Rat DIC Model The authors investigated the effect of bone marrow-derived mesenchymal stem cells on disseminated intravascular coagulation (DIC) model rats and further exploreD the underlying mechanism. A rat model of lipopolysaccharide-induced DIC was successfully established, as indicated by impaired plasma hemostatic parameters and damaged organ functions in rats. [Cell Death Dis] Full Article A Mesenchymal Stem Cell Line (B10) Increases Angiogenesis in a Rat MCAO Model Researchers investigated the effects of B10 transplantation on cerebral angiogenesis in a rat middle cerebral artery occlusion (MCAO) model. B10 cells were transplanted intravenously 24h after MCAO. Immunofluorescence staining results showed that compared to PBS-groups, vWF positive vessel and endoglin positive new vessels were increased in B10-transplanted MCAO groups in the lesion areas. [Exp Neurol] Abstract Scientists compared the protective effects of intratracheally administered MSCs vs. MSC extracellular vesicles in a hyperoxia-induced rat model of bronchopulmonary dysplasia. The sham-treated hyperoxia-exposed animals showed reductions in total surface area of alveolar air spaces, and total number of alveoli, and an increased mean alveolar volume. [Am J Physiol Lung Cell Mol Physiol] Abstract Researchers transplanted a MSC line (B10) in a rat middle cerebral artery occlusion model and checked the proliferation and migration of neuronal progenitor cells (NPCs). B10 transplantation increased NPCs in the subventricular zone and their migration towards the lesion area at an earlier time. [Sci Rep] Full Article After transplantation of BMSCs and low-intensity pulsed ultrasound (LIPUS)-BMSCs postinjury, locomotor function was significantly improved in LIPUS-BMSCs transplantation group with higher level of brain-derived neurotrophic factor and nerve growth factor in the epicenter, and the expression of neurotrophic receptor was also enhanced. [CNS Neurosci Ther] Abstract | |
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REVIEWSMesenchymal Stem Cells for Periodontal Tissue Regeneration in Elderly Patients Aging progressively decreases the proliferative and differentiation potential of MSCs and diminishes their regenerative capacity, which represents a limiting factor for their endogenous use in elderly patients. Therefore, tissue regeneration therapy with MSCs in this age group may require a cellular source without the physiological limitations that MSCs exhibit in aging. [J Gerontol A Biol Sci Med Sci] Abstract The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells in Premature Ovarian Failure With the development of regenerative medicine, a variety of mesenchymal stem cells are increasingly considered for the treatment of premature ovarian failure (POF). The authors discuss the possible therapeutic mechanisms of BMSCs for POF, migration, antiapoptosis, antifibrosis, angiogenesis, anti-inflammation, immunoregulation, and oxidative stress, which provide the theoretical basis for further study and clinical therapy. [Stem Cell Res Ther] Full Article Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSDepartment of Defense Grant for Clinical Trial of Stem Cell Therapy for Eye Injuries Researchers at the University of Illinois at Chicago have received a four-year, $5.25 million grant from the U.S. Department of Defense to lead a multi-site clinical trial to test the efficacy of a stem cell-based treatment for eye injuries. [The Board of Trustees of the University of Illinois] Press Release Pall Corporation has progressed a strategic partnership with the University College London (UCL) Biochemical Engineering department with the creation of the UCL-Pall Biotech Centre of Excellence for research and training. [Pall Corporation (PR Newswire)] Press Release | |
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POLICY NEWSWas Cancer Scientist Fired for Challenging Lab Chief over Authorship? Rutgers University last month terminated a veteran cancer scientist in retaliation, the researcher says, for challenging a powerful principal investigator on the authorship of a paper apparently accepted for publication in Nature. The researcher is now deciding whether to appeal her dismissal in arbitration through her union or to sue Rutgers. [ScienceInsider] Editorial Peer-Reviewed Homeopathy Study Sparks Uproar in Italy A study that claims to show that a homeopathic treatment can ease pain in rats has caused uproar after it was published in a peer-reviewed journal. Groups that promote homeopathy in Italy, where there is currently a debate about how to label homeopathic remedies, have held the study up as evidence that the practice works. But several researchers have cast doubt on its claims. [Nature News] Editorial
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JOB OPPORTUNITIESPostdoctoral Fellow – Bone Regeneration (University of Michigan) Assistant Professor – Department of Stem Cell and Regenerative Biology (Harvard University) Postdoctoral Fellows – Regenerative Medicine (Stanford University) Faculty Positions – Biomedical Engineering (Pennsylvania State University) Tenure Track Assistant Professor – Regenerative Biology (Massachusetts General Hospital) Tenure-Track Faculty Position – Stem Cell Biology (Children’s Research Institute at UT Southwestern) Assistant Professor – Stem Cell and Regenerative Biology (Columbia University) Postdoctoral Researcher – Interdisciplinary (Oregon Health & Science University) Faculty Positions – Biomedical Research (Memorial Sloan Kettering Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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