 | | Vol. 9.08 – 3 March, 2023 |
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| Using whole-genome analysis of 37 patients with metastatic colorectal cancer (mCRC) treated with the chemotherapy trifluridine/tipiracil, researchers identified KRAS codon G12 mutations as a potential biomarker of resistance.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified cell migration-inducing and hyaluronan-binding protein (CEMIP) interacting with GRAF1, and the combination of high-CEMIP and low-GRAF1 predicted poor survival of patients.
[Cell Death & Disease] |
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| The authors reported a novel mechanism of lysine acetyltransferase 8 (KAT8) on lipolysis involving in its acetylation by general control non-repressed protein 5 and its deacetylation by sirtuin 6.
[Cell Death & Disease] |
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| Investigators examined the effects of lactoferrin on the migration and invasion of colon tumor cells under high concentration of glucose.
[Journal of Translational Medicine] |
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| Taking advantage of a large panel of human metastatic colorectal cancer xenografts and matched stem-like cell cultures, researchers showed that overexpression of microRNA 483-3p, encoded by a frequently amplified gene locus, confered an aggressive phenotype.
[Molecular Oncology] |
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| Scientists presented the first report that mesoderm posterior basic helix-loop-helix transcription factor 2 (MESP2) bound to transcription factor 7-like 2 to inhibit the activation of the TCF4/beta-catenin transcriptional complex.
[Cell Death Discovery] |
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| Investigators subcutaneously transplanted the MC38 colon cancer cells into C57BL/6 mice, intraperitoneally injected anti-PD-1 antibody, and then isolated immune checkpoint blockade-resistant subclones from the recurrent tumors.
[Journal of Gastroenterology] |
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| The authors revealed that artificial circular single-stranded DNA could restore multiple tumor suppressor genes to inhibit tumor malignant progression by adsorbing miRNA.
[Cancer Medicine] |
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| Researchers dissected possible interplay between LINC00858/miR-132-3p/IGF2BP1 via bioinformatics approaches. They analyzed the mRNA expression of LINC00858, miR-132-3p, and IGF2BP1 through qRT-PCR.
[Biological Chemistry] |
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| Scientists discuss the current understanding of mechanisms of biogenesis and distinctive features of extrachromosomal circular DNA in colorectal cancer.
[Oncogene] |
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| Carleton University researchers have received over $3 million from the Canadian Institutes for Health Research (CIHR). The funding will support projects developing solutions to the prevalence of diabetes, chronic pain, gut health disturbances and brain injuries.
[Carleton University] |
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| Researchers in the United Kingdom (UK) breathed a cautious sigh of relief yesterday after the government struck a deal with the European Union (EU) to fix post-Brexit disputes over issues including trade across Northern Ireland’s border.
[ScienceInsider] |
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| March 19 – 23, 2023
Banff, Alberta, Canada |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University of Houston – Houston, Texas, United States |
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| | University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
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| | Massachusetts General Hospital – Boston, Massachusetts, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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