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| Researchers showed that the matricellular protein cellular communication network factor 1 (CCN1)/CYR61 coordinately regulated intestinal stem cells proliferation and differentiation through distinct pathways emanating from CCN1 interaction with integrins αvβ3/αvβ5.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that intracellular C5 was cleaved by cathepsin D to produce C5a in lysosomes and endosomes of colonic cancer cells.
[Cell Reports] |
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| In vitro, NADPH oxidase 1 (NOX1) silencing alleviated reactive oxygen species accumulation and the apoptosis of human colonic epithelial cells, while NOX1 overexpression accelerated oxidative stress injury of NCM460 cells.
[Cell Biology and Toxicology] |
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| Investigators discovered that calreticulin (CALR) was highly expressed in gastric cancer (GC) tissues and related to lymph node metastasis and patients’ terrible prognosis. The introduction of CALR dramatically promoted GC cell migration in vitro and in vivo, while the repression of CALR got the opposite effects.
[Oncogenesis] |
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| Histone deacetylase 4 (HDAC4) was upregulated in gastric cancer (GC) and correlated with poor prognosis. In vitro and in vivo assays showed that HDAC4 contributed to the malignant phenotype of GC cells.
[British Journal of Cancer] |
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| The authors established trastuzumab-resistant cells and patient-derived xenografts models to measure metabolic levels and vascular density and shape.
[British Journal of Cancer] |
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| RNA-sequencing analyses of ALDHPositive colon cancer stem cells (CSCs) from colon cancer patient-derived organoids and xenografts showed CSCs to be enriched for neural development genes.
[iScience] |
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| Using a spaceflight analogue low fluid shear culture system, scientists investigated the effect of Low Shear Modeled Microgravity culture on the colonization of Salmonella Typhimurium in a 3D biomimetic model of human colonic epithelium containing macrophages.
[Frontiers in Cellular and infection Microbiology] |
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| Researchers investigated the biological functions of a HER2 mutation, G776S, of unknown pathological significance, which was detected together with APC mutation by cancer genome sequencing of samples from a colorectal cancer patient.
[Scientific Reports] |
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| The authors highlight some of the established methods and also some exciting novel perspectives on organoids in the fields of gastroenterology.
[Gut] |
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| Legend Biotech Corporation announced that the US FDA has cleared its investigational new drug (IND) application to evaluate LB1908 in a Phase I clinical trial in the United States.
[Legend Biotech Corporation] |
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| Two Vanderbilt University Medical Center researchers have received awards from the AGA Foundation, the charitable arm of the American Gastroenterological Association.
[Vanderbilt University Medical Center] |
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| September 15 – 17, 2022
Dublin, Ireland, United Kingdom |
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| | Flanders Institute for Biotechnology – Ghent, Belgium |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Weill Cornell Medicine – New York, New York, United States |
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| | The Ohio State University – Columbus, Ohio, United States |
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