 | | Vol. 8.13 – 8 April, 2022 |
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| Investigators showed that the aryl hydrocarbon receptor was important for the termination of the regenerative response and the reacquisition of mature epithelial cell identity post-injury in vivo and in organoid cultures in vitro.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed a synthetic lethal drug screening with SMAD4-isogenic colorectal cancer cells and found that aurora kinase A inhibition was synthetic lethal with SMAD4 loss.
[Oncogene] |
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| Researchers constructed colorectal cancer PDOs and selected the Kruppel-like factor 5 (KLF5) inhibitor ML264 as the research object based on the results of an in vitro drug screening assay.
[Cell Death & Disease] |
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| Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.
[Stem Cell Reports] |
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| Scientists explored the ability of gastric cancer (GC) cell-derived extracellular vesicles-mediated microRNA-129-5p/E2F transcription factor 7/mitogen-activated protein kinase/extracellular regulated protein kinase (MAPK/ERK) axis to affect the peritoneal metastasis of GC by delivering lncRNA small nucleolar RNA host gene 12 (SNHG12).
[Cell Death Discovery] |
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| The authors found that high ZIC2 expression was not only associated with poor prognosis, relapse-free survival and advanced metastasis but was also an independent prognostic factor in colorectal cancer patients.
[Experimental Cell Research] |
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| Researchers investigated the effects of glyphosate-based herbicides on antioxidant capacity, inflammatory cytokines, and autophagy of porcine intestinal epithelial cells (IPEC-J2) and its molecular mechanism.
[Environmental Toxicology] |
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| Scientists found that the expression of miR-1538 was significantly down-regulated in colorectal cancer tissues and cells, and its expression level was significantly correlated with tumor size, clinical stage and prognosis.
[Biochemical and Biophysical Research Communications] |
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| Researchers investigated the role of heme in heme oxygenase-1 (HO-1) and HO-2 induced colorectal carcinogenesis and the clinicopathological significance of their expressions in patients with colorectal carcinoma.
[Pathology Research and Practice] |
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| The authors review the recent research advances of therapies based on the mesenchymal stem cell-Exo for treating ulcerative colitis and colorectal cancer.
[Stem Cell Research & Therapy] |
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| Investigators summarize current knowledge on the molecular network of colorectal cancer (CRC), including cellular signaling pathways, CRC microenvironment modulation, epigenetic changes, and CRC biomarkers for diagnosis and predictive/prognostic use.
[Frontiers in Oncology] |
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| Processa Pharmaceuticals, Inc., announced that it has enrolled its first patient in the Phase IIA clinical trial of PCS12852 in patients with moderate to severe gastroparesis.
[Processa Pharmaceuticals, Inc.] |
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| June 9 – 13, 2022
Washington, DC, United States |
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| | The George Washington University – Washington, DC, United States |
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| | TU Dresden – Dresden, Germany |
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| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | Princeton University – Princeton, New Jersey, United States |
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| | Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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