 | | Vol. 8.07 – 25 February, 2022 |
| |
|
|
| Researchers provided a detailed technical pipeline and protocol for using the CRISPR–Cas9 genome editing system to knock out a gene of interest specifically in human intestinal tissue-derived enteroids by lentiviral transduction and single-cell cloning.
[Nature Protocols] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists revealed the roles of O-GlcNAcylation in glucose absorption by the small intestine and elucidated the mechanism by which O-GlcNAcylation regulated sodium-glucose cotransporter 1 (SGLT1) expression.
[Molecular Metabolism] |
|
|
|
| Knockdown of CCDC12 could significantly reduce proliferation, migration, invasion, and tumorigenicity of colon cancer cells, while exogenous overexpression of CCDC12 had the opposite effect.
[Cell Death & Disease] |
|
|
|
| Caco-2 cell monolayers were incubated with TNFα, in the absence or presence of curcumin. TNFα caused an increase in interleukin (IL)-6 and IL-8 release which was inhibited by curcumin in a dose-dependent manner.
[Molecular Nutrition & Food Research] |
|
|
|
| Scientists performed cytotoxicity, cell colony, cell cycle and apoptosis assays in various cell lines or primary immune cells.
[Biomedicine & Pharmacotherapy] |
|
|
|
| Cucurbitacin E (CE) belongs to the triterpenoids and has received substantial attention for its antineoplastic property. The authors revealed that CE significantly induced cellular senescence in colorectal cancer cells.
[Journal of Agricultural and Food Chemistry] |
|
|
|
| Blocking large tumor suppressor kinases 1/2-YAP1 led to the loss of F-box and WD repeat domain-containing 5 (FBXW5)-mediated regulation of the Hippo pathway and partial functions.
[Cell Death Discovery] |
|
|
|
| In vitro, the AZD6738/5‑fluorouracil combination increased the number of mitotic cells according to flow cytometry, decreased the checkpoint kinase 1 phosphorylation levels and increased cleaved caspase‑3 and phosphorylated form of H2A.X variant histone levels according to western blotting, and decreased the proliferation rate of four colon cancer cell lines according to cell viability experiments.
[Oncology Reports] |
|
|
|
| Scientists determined the epigenetic features of the HNF1A gene loci, and expression and cellular localization of HNF1A-AS1 RNA, HNF1A RNA, and HNF1A protein in colorectal cancer and normal colon epithelial cells.
[IUBMB Life] |
|
|
|
| Cell Counting Kit‑8 assays were performed to analyze cell viability, and flow cytometry and a TUNEL assay was performed to evaluate cell apoptosis.
[Molecular Medicine Reports] |
|  |
|
|
|
| The authors discuss the key milestones in the medical management of Crohn’s disease.
[Therapeutic Advances in Gastroenterology] |
|
|
|
|
| NovoBiome announced that it has signed a new collaboration with the French National Institute of Health and Medical Research (Inserm), a scientific and technological institute which operates under the joint authority of the French Ministries of Health and Research.
[NovoBiome, Inc. (GlobeNewswire, Inc.)] |
|
|
|
|
| March 13 – 18, 2022
Ventura, California, United States |
|
|
|
|
|
| Gilead Sciences, Inc. – Foster City, California, United States |
|
|
|
| Baylor College of Medicine – Houston, Texas, United States |
|
|
|
| | University of Copenhagen – Copenhagen, Denmark |
|
|
|
| The University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| University of North Dakota – Grand Forks, North Dakota, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
