 | | Vol. 8.01 – 14 January, 2022 |
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| Investigators employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human intestinal stem cells from the duodenum and rectum.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that in a high-turnover tissue, severe damage to the differentiated compartment induced progenitors to transiently acquire a unique transcriptional and morphological postmitotic state.
[Developmental Cell] |
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| The authors found that CDC42 loss initiated in intestinal stem cells caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports] |
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| Researchers identified a mechanism of redox-dependent alternative internalization that promoted the internalization and degradation of the purinergic P2Y6 receptor.
[Science Signaling] |
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| Scientists found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients.
[Cell Death & Disease] |
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| Scientist analyzed immune subtypes and immune evasion via neoantigen-related mechanisms and identified a distinctive cancer subtype characterized by immune evasion and very poor overall survival.
[iScience] |
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| Researchers utilized an antigen-independent strategy for circulating tumor cell (CTC) isolation from metastatic gastric cancer patients involving a size-dependent recovery of CTCs and a single cell isolation technique.
[Communications Biology] |
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| Researchers explored the involvement of epithelial GPR120 in the colorectal cancer development. Both in vitro and in vivo experiments were conducted to mimic the conditional deletion of the receptor from gut epithelium.
[Scientific Reports] |
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| Scientists designed the first hydrophobic tagging-based PDEδ degraders. Compound 17c efficiently bound to PDEδ and induced degradation of PDEδ in SW480 colon cancer cells.
[ACS Medicinal Chemistry Letters] |
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| The authors provide an overview of the epidemiological evidence to date which comprises 16 cohort studies of the effects of physical activity on colon cancer outcomes including cancer recurrence, cancer-specific and overall survival.
[Critical Reviews in Oncology Hematology] |
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| G-Tech Medical, announced US FDA 510(k) clearance of its Wireless Patch System for non-invasive myoelectric activity measurement.
[G-tech Medical] |
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| February 15-16, 2022
Virtual |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Princess Margaret Cancer Centre – Toronto, Ontario, Canada |
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| KU Leuven – Leuven, Belgium |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
