 | | Vol. 11.04 – 14 March, 2025 |
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| A large human gastric intestinal metaplasia organoid cohort, their clonal derivatives, and normal gastric organoids for comparison were established. Comprehensive multi-omics profiling and functional characterization were performed.
[Gut] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Scientists uncovered a previously unidentified role of KAT7 in the regulation of procentriole formation and colorectal tumorigenesis via competitive antagonism of its crotonylation against acetylation.
[Nature Communications] |
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| Researchers introduced a nanozyme-functionalized microalgal biohybrid microrobot with a novel mechanism for treating inflammatory bowel disease by leveraging the therapeutic advantages of microalgae and nanozymes.
[Biomaterials] |
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| Colorectal cancer cells treated with oxaliplatin exhibited increased ubiquitin-specific protease 10 (USP10) nuclear expression. USP10 bound to XPA binding protein 2 (XAB2) and deubiquitinated XAB2 K48-linked polyubiquitination at K593, thereby stabilizing XAB2 by reducing its degradation.
[Journal of Experimental & Clinical Cancer Research] |
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| This Phase II study evaluated the efficacy and safety of combining neoadjuvant durvalumab with docetaxel, oxaliplatin, and S-1, followed by surgery and adjuvant durvalumab plus S-1 chemotherapy, for resectable locally advanced gastric cancer.
[Journal for Immunotherapy of Cancer] |
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| Researchers demonstrated that histone 3 lysine 23 succinylation (H3K23su) was a critical epigenetic determinant of 5-fluorouracil (5-FU) resistance in colon cancer cells, exerting its effects through the modulation of critical genes and transcription factors.
[Experimental & Molecular Medicine] |
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| The authors identified that c-Kit+ cells were a heterogeneous entity and possessed stemness potency to differentiate into the entire spectrum of epithelial cells and renew the homeostatic colon.
[Cell Death & Differentiation] |
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| Scientists demonstrated that E74-like factor 1 (ELF-1) deficiency in mice led to exacerbated DSS-induced colitis, marked by inflammation dominated by neutrophil infiltration and activation of IL-17 signaling pathways in various immune cells, including Th17, ILC3, γδT, and NKT cells.
[Communications Biology] |
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| The significance of TL1A:DR3 signaling in the pathogenesis of IBD is supported by several converging lines of evidence. The authors provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD.
[Gut] |
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| PDS Biotechnology Corporation announced that the US FDA has cleared its Investigational New Drug application to evaluate a combination of Versamune® MUC1 its novel investigational MUC1-targeted immunotherapy candidate + PDS01ADC to treat MUC1-positive, metastatic colorectal carcinoma.
[PDS Biotechnology Corporation] |
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| Tempest Therapeutics, Inc. announced that the Cancer Prevention Clinical Trials Network received a “Study May Proceed” letter from the US FDA to evaluate TPST-1495, the company’s novel dual receptor inhibitor of prostaglandin signaling, in a Phase II clinical trial for the treatment of patients with FAP.
[Tempest Therapeutics, Inc.] |
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| May 6-8, 2025
Boston, Massachusetts, United States |
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| | Umeå University – Umeå, Sweden |
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| | King’s College London – London, England, United Kingdom |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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