Human Immunology News Volume 12.45 | Dec 03 2024

December 3, 2024

2024-12-03 | HIN 12.45

Human Immunology News by STEMCELL Technologies

Vol. 12.45 – 3 December, 2024

TOP STORY

Safety and Activity of CTX130, a CD70-Targeted Allogeneic CRISPR-Cas9-Engineered CAR T Cell Therapy, in Patients with Relapsed or Refractory T Cell Malignancies (COBALT-LYM): A Single-Arm, Open-Label, Phase I, Dose-Escalation Study

Researchers assessed the safety and activity of CTX130, a CD70-directed, allogeneic CAR immunotherapy manufactured from healthy donor T cells, in patients with relapsed or refractory T cell lymphoma.
[Lancet Oncology]

Abstract

PUBLICATIONSListed by the impact factor of the journal

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

Researchers determined the frequency and within-patient variability of corticosteroid-responsive type 1 (T1)-high, T2-high, and T1/T2-high asthma endotypes and whether virally influenced T1-high disease influenced corticosteroid response in asthma.
[American Journal of Respiratory and Critical Care Medicine]

Abstract

Efficacy and Safety of Switching to Daily Bictegravir Plus Lenacapavir From a Complex Human Immunodeficiency Virus Treatment Regimen: A Randomized, Open-Label, Multicenter Phase II Study (ARTISTRY-1)

ARTISTRY-1 was a Phase II/III, operationally seamless, randomized, open-label, multicenter, active-controlled study. Phase II of the study enrolled adults with plasma HIV-1 RNA <50 copies/mL receiving a complex antiretroviral therapy regimen for ≥6 months.
[Clinical Infectious Diseases]

Full Article

Dominant Negative Variants in ITPR3 Impair T Cell Ca²⁺ Dynamics Causing Combined Immunodeficiency

The importance of calcium as a second messenger in T cell signaling was exemplified by genetic deficiencies of STIM1 and ORAI1, which abolished store-operated calcium entry resulting in combined immunodeficiency.
[Journal of Experimental Medicine]

Full Article

Novel Tri-Specific T Cell Engager Targeting IL-13Rα2 and EGFRvIII Provides Long-Term Survival in Heterogeneous GBM Challenge and Promotes Antitumor Cytotoxicity with Patient Immune Cells

Researchers described novel trivalent antibodies, DNA-encoded tri-specific T cell engagers, targeting two glioblastoma multiforme antigens, epidermal growth factor receptor variant III (EGFRvIII) and IL-13Rα2, and engaging T cells through CD3.
[Journal for Immunotherapy of Cancer]

Full Article Press Release

Integrated Single-Cell Transcriptome and TCR Profiles of Hepatocellular Carcinoma Highlight the Convergence on Interferon Signaling during Immunotherapy

Scientists comprehensively analyzed paired single-cell RNA transcriptome and T cell repertoire profiles from 14 hepatocellular carcinoma ascites samples, collected from seven patients before and after treatment with the combination of sintilimab and bevacizumab.
[Journal for Immunotherapy of Cancer]

Full Article

Long-Term Follow Up in Anti-Contactin-1 Autoimmune Nodopathy

Investigators analyzed long-term clinical and biomarker features of anti-contactin-1 (CNTN1) autoimmune nodopathy. Patients with anti-CNTN1⁺ autoimmune nodopathy detected in the laboratory from which clinical information was available were included.
[Annals of Neurology]

Abstract

In Human CD4⁺ T Cells, Omeprazole Suppresses Proliferation, Downregulates V-ATPase, and Promotes Differentiation toward an Autoimmunity-Favoring Phenotype

Triggered by findings indicating a correlation between proton pump inhibitors usage and susceptibility to infectious or autoimmune diseases, investigators studied the impact of a pharmacological concentration of omeprazole on human CD4⁺ T cells.
[International Immunopharmacology]

Abstract

Assessing Human B Cell Responses to Influenza Virus Vaccines and Adjuvants in a PBMC-Derived In Vitro Culture System

Scientists assessed whether B cells present in peripheral blood mononuclear cells responded to vaccines and reflected the effects of different vaccine formulations and adjuvants.
[Vaccine]

Full Article

REVIEWS

Rheumatoid Arthritis: A Review of the Key Clinical Features and Ongoing Challenges of the Disease

The authors provide a comprehensive overview of rheumatoid arthritis, covering new research on the ‘pre-clinical’ phase of the disease, as well as its epidemiology, pathogenesis, clinical manifestations, diagnosis, imaging, and management strategies.
[Panminerva Medica]

Abstract

INDUSTRY AND POLICY NEWS

Moffitt Patient Is First To Receive Second CAR T Therapy for Ovarian Cancer

Marisol Gallagher, with Drs. Robert Wenham and Monica Avila, received a second round of CAR T-cell therapy 18 months after her first round. Her care team hopes the second infusion will cure her ovarian cancer once and for all.
[Moffitt Cancer Center]

Press Release

FEATURED EVENT

Human Immunology News Volume 12.45 | Dec 03 2024

Safety and Activity of CTX130, a CD70-Targeted Allogeneic CRISPR-Cas9-Engineered CAR T Cell Therapy, in Patients with Relapsed or Refractory T Cell Malignancies (COBALT-LYM): A Single-Arm, Open-Label, Phase I, Dose-Escalation Study

Type 1 Immune Responses Related to Viral Infection Influence Corticosteroid Response in Asthma

Efficacy and Safety of Switching to Daily Bictegravir Plus Lenacapavir From a Complex Human Immunodeficiency Virus Treatment Regimen: A Randomized, Open-Label, Multicenter Phase II Study (ARTISTRY-1)

Dominant Negative Variants in ITPR3 Impair T Cell Ca²⁺ Dynamics Causing Combined Immunodeficiency

Novel Tri-Specific T Cell Engager Targeting IL-13Rα2 and EGFRvIII Provides Long-Term Survival in Heterogeneous GBM Challenge and Promotes Antitumor Cytotoxicity with Patient Immune Cells

Integrated Single-Cell Transcriptome and TCR Profiles of Hepatocellular Carcinoma Highlight the Convergence on Interferon Signaling during Immunotherapy

Long-Term Follow Up in Anti-Contactin-1 Autoimmune Nodopathy

In Human CD4⁺ T Cells, Omeprazole Suppresses Proliferation, Downregulates V-ATPase, and Promotes Differentiation toward an Autoimmunity-Favoring Phenotype

Assessing Human B Cell Responses to Influenza Virus Vaccines and Adjuvants in a PBMC-Derived In Vitro Culture System

Rheumatoid Arthritis: A Review of the Key Clinical Features and Ongoing Challenges of the Disease

Moffitt Patient Is First To Receive Second CAR T Therapy for Ovarian Cancer

Translating Targeted Therapies in Combination with Radiotherapy

> See All Events

Bioinformatician – Rheumatic Diseases

Postdoctoral Researcher – Prostate Cancer Immune Modulation

PhD Positions – Infection Biology, Immunology, Microbiology, Parasitology, Epidemiology

Postdoctoral Research Associate – Metabolism and TME Interactions during Cancer Progression

Faculty Position – Translational Cancer Research

> See All Jobs