Human Immunology News Volume 12.23 | Jun 18 2024

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    2024-06-18 | HIN 12.23


    Human Immunology News by STEMCELL Technologies
    Vol. 12.23 – 18 June, 2024
    TOP STORY

    Duvelisib plus Romidepsin in Relapsed/Refractory T Cell Lymphomas: A Phase Ib/IIa Trial

    Researchers conducted a Phase Ib/IIa study of duvelisib in combination with either romidepsin or bortezomib in patients with relapsed/refractory T cell lymphomas and found that the addition of romidepsin, but not bortezomib, appeared to increase efficacy while attenuating PI3K inhibitor-driven toxicity.
    [Nature Medicine]

    Full Article
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    DNA of Neutrophil Extracellular Traps Promote NF-κB-Dependent Autoimmunity via cGAS/TLR9 in Chronic Obstructive Pulmonary Disease

    Investigators elucidated the immunoregulatory mechanism of neutrophil extracellular traps in chronic obstructive pulmonary disease (COPD), employing human neutrophils, airway epithelial cells, dendritic cells, and a long-term cigarette smoke-induced COPD mouse model.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Schlafen 11 Triggers Innate Immune Responses through Its Ribonuclease Activity upon Detection of Single-Stranded DNA

    Scientists reported that intracellular ssDNA triggered cytokine expression and cell death in a CGT motif–dependent manner. They identified Schlafen 11 as an ssDNA-activated RNase, which was essential for the innate immune responses induced by intracellular ssDNA and adeno-associated virus infection.
    [Science Immunology]

    Abstract

    Somatic Mutations Associate with Clonal Expansion of CD8+ T Cells

    Investigators examined somatic mutations in CD4+ and CD8+ T cells from 90 patients with hematological and immunological disorders and used T cell receptor and single-cell sequencing to link mutations with T cell expansions and phenotypes.
    [Science Advances]

    Full Article

    Successful Use of Anti-CD19 CAR T Cells in Severe Treatment-Refractory Stiff-Person Syndrome

    To investigate clinical and immunological effects of anti-CD19 CAR T cell use in treatment-refractory stiff-person syndrome (SPS), a 69-year-old female with a 9-year history of treatment-refractory SPS with deteriorating episodes of stiffness received an infusion of autologous anti-CD19 CAR T cells.
    [Proceedings of The National Academy of Sciences of The United States of America]

    Full Article

    Synergistic Immunochemotherapy Targeted SAMD4B-APOA2-PD-L1 Axis Potentiates Antitumor Immunity in Hepatocellular Carcinoma

    Scientists proposed a synergistic immunochemotherapy that exerted a potent antitumor effect for advanced hepatocellular carcinoma in clinical practice based on three common antitumor drugs and found that new synergistic immunochemotherapy had better three-year overall survival than the control group.
    [Cell Death & Disease]

    Full Article

    The Effect of Type 1 Diabetes Protection and Susceptibility Associated HLA Class II Genotypes on DNA Methylation in Immune Cells

    Researchers examined genome-wide DNA methylation by microarrays to cover over 850,000 CpG sites in the CD4+ T cells and CD19+ B cells of healthy subjects homozygous either for DRB1*15-DQA1*01-DQB1*06:02, DRB1*03-DQA1*05-DQB1*02, or DRB1*04:01-DQA1*03-DQB1*03:02.
    [HLA]

    Full Article

    Innate Immune Sensing of AAV Vectors

    Scientists showed that adeno-associated virus (AAV) vectors could initiate several and likely redundant innate immune pathways resulting in an exaggerated adaptive immune response.
    [Human Gene Therapy]

    Abstract

    Evaluation of Immune Profiles Associated with Control of Mycobacterial Growth in Systemic Lupus Erythematosus (SLE) Patients

    Investigators presented a pilot study evaluating intracellular cytokine responses and ex vivo ability to control mycobacterial growth using peripheral blood mononuclear cells collected from systemic lupus erythematosus (SLE) patients before and during SLE treatment.
    [Tuberculosis]

    Abstract
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    REVIEWS

    Platelets in Kawasaki Disease: Mediators of Vascular Inflammation

    The authors review the role of platelets in Kawasaki disease and discuss progress in understanding the immune-effector role of platelets in amplifying inflammation related to Kawasaki disease vasculitis and therapeutic strategies targeting platelets or platelet-derived molecules.
    [Nature Reviews Rheumatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Asgard Therapeutics Selects Exothera to Bring their Viral Vector-Based Immunotherapy Candidate AT-108 to Clinical Trial Stage

    Asgard Therapeutics announced it selected Exothera S.A., a leading provider of nucleic acids and viral vector development and manufacturing services, for process development up to clinical Phases I/II manufacturing of its candidate AT-108, based on viral vector technology.
    [Life Science Newswire]

    Press Release
    FEATURED EVENT

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    July 14-19, 2024
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    JOB OPPORTUNITIES

    Postdoctoral Associate – Scleroderma Vasculopathy

    Boston University – Boston, Massachusetts, United States

    Professor – Science Research

    KU Leuven – Leuven, Belgium

    Postdoctoral Research Assistant – Immuno-Oncology

    University of Oxford – Oxford, England, United Kingdom

    Research Technician – CAR T Cell Therapy

    Amsterdam UMC – Amsterdam, Netherlands/p>

    PhD Position – ANCA-Associated Vasculitides

    University Medical Centre Groningen – Groningen, Netherlands

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