Human Immunology News Volume 12.19 | May 21 2025

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    Jamie Kang
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    2024-05-21 | HIN 12.18


    Human Immunology News by STEMCELL Technologies
    Vol. 12.19 – 21 May, 2024
    TOP STORY

    Identification of a Clinically Efficacious CAR T Cell Subset in Diffuse Large B Cell Lymphoma by Dynamic Multidimensional Single-Cell Profiling

    Using infusion products of individuals with large B cell lymphoma, the authors integrated functional profiling using timelapse imaging microscopy in nanowell grids with subcellular profiling and single-cell RNA sequencing to identify a signature of multifunctional CD8+ T cells.
    [Nature Cancer]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    γδ T Cell Profiling in a Cohort of Preterm Infants Reveals Elevated Frequencies of CD83+ γδ T Cells in Sepsis

    γδ T cells were investigated in a longitudinal cohort of preterm neonates using next-generation sequencing, flow cytometry, and functional assays. During the first year of life, the Vγ9Vδ2 T cell subset showed dynamic phenotypic changes and elevated levels of fetal-derived Vγ9Vδ2 T cells in infants with sepsis.
    [Journal Of Experimental Medicine]

    Full Article

    Molecular Subgroups of T Cell Acute Lymphoblastic Leukemia in Adults Treated According to Pediatric-Based GMALL Protocols

    Researchers presented a homogenously treated cohort of 230 adult T-lineage lymphoblastic leukemia patients characterized on transcriptome, and partly on DNA methylation and gene mutation level in correlation with clinical outcome.
    [Leukemia]

    Full Article

    IL-3-Driven T Cell–Basophil Crosstalk Enhances Antitumor Immunity

    Scientists investigated the role of interleukin (IL)-3 in orchestrating anti-tumor immunity through cytotoxic T lymphocyte (CTL) modulation. Intratumoral CTLs underwent a progressive decline in IL-3 production, which was correlated with impaired cytotoxic function.
    [Cancer Immunology Research]

    Abstract

    A Bispecific Antibody Targeting HLA-DQ2.5-Gluten Peptides Potently Blocks Gluten-Specific T Cells Induced by Gluten Ingestion in Patients with Celiac Disease

    Investigators assessed the ability of DONQ52 to inhibit coeliac disease patient-derived T cell responses to the most immunogenic gluten peptides encompassing immunodominant T cell epitopes.
    [Clinical Immunology]

    Abstract

    Development and Interpretation of a Pathomics-Driven Ensemble Model for Predicting the Response to Immunotherapy in Gastric Cancer

    Scientists developed and validated a pathomics-driven ensemble model for predicting the response to immune checkpoint inhibitors in gastric cancer, using H&E-stained whole slide images.
    [Journal Of Immunotherapy of Cancer]

    Full Article

    Keratinocytes Present Staphylococcus aureus Enterotoxins and Promote Malignant and Non-Malignant T Cell Proliferation in Cutaneous T Cell Lymphoma

    Expression of HLA-DR, high-affinity receptors for Staphylococcal enterotoxins (SE), by keratinocytes correlated with IFN-γ expression in the tumor microenvironment. Importantly, IFN-γ induced HLA-DR, SE-binding, and SE-presentation by keratinocytes to malignant T cells from Sézary syndrome patients.
    [Journal Of Investigative Dermatology]

    Full ArticleGraphical Abstract

    Bevacizumab Induces Ferroptosis and Enhances CD8+ T Cell Immune Activity in Liver Cancer via Modulating HAT1 and Increasing IL-9

    Researchers investigated whether and how bevacizumab regulated ferroptosis and immune activity in liver cancer. They performed RNA-sequencing in bevacizumab-treated human liver cancer cell line HepG2 cells, and found that bevacizumab significantly altered the expression of a number of genes.
    [Acta Pharmacologica Sinica]

    Abstract

    Fulminant Hepatitis in a Hepatitis B Surface Antigen-Positive Patient with Adult T-Cell Leukemia-Lymphoma after Mogamulizumab Monotherapy

    Scientists reported a case of fulminant hepatitis in a hepatitis B surface antigen-positive patient with aggressive adult T cell leukemia-lymphoma who received monotherapy with an anti-CCR4 monoclonal antibody, mogamulizumab, with decreased hepatitis B virus- DNA levels by entecavir prophylaxis.
    [Hepatology Research]

    Abstract
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    REVIEWS

    Arming Vδ2 T Cells with Chimeric Antigen Receptors to Combat Cancer

    The authors present how arming Vδ2-T cells might be the basis for next-generation immunotherapies against solid tumors. They also discuss the clinical potential of Vδ2 CAR-T cells to overcome the current limitations of immunotherapy in solid tumors.
    [Clinical Cancer Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    CXCR4 Chemokine Antagonist Scores a First FDA Approval for WHIM Syndrome

    The FDA has approved X4 Pharmaceuticals’ mavorixafor (Xolremdi) for a rare immune deficiency disorder that leads to recurrent, life-threatening infections. Mavorixafor is the first drug to gain FDA approval for warts, hypogammaglobulinemia, infections and myelokathexis (WHIM) syndrome.
    [Nature Reviews Drug Discovery]

    Press Release

    Dupixent® (dupilumab) sBLA Accepted for FDA Priority Review for Treatment of Adolescents with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP)

    Regeneron Pharmaceuticals, Inc. and Sanofi announced that the US FDA has accepted for Priority Review the supplemental Biologics License Application for Dupixent® as an add-on maintenance treatment for adolescents aged 12 to 17 years with inadequately controlled CRSwNP.
    [Regeneron Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Channels and Transporters in Immunity

    June 16 – 20, 2024
    Saint Paul, Minnesota, United States

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    JOB OPPORTUNITIES

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    Boston University – Boston, Massachusetts, United States

    Research Associate – Sight-Threatening Uveitis and Inflammatory Arthritis

    University of Bristol – Bristol, England, United Kingdom

    PhD Student – Immunology and Adoptive Cell Therapy

    Karolinska Institute – Solna, Sweden

    Research Fellow – Treg Therapies Group

    Monash University – Melbourne, Victoria, Australia

    Research Associate – AIDS Clinical Trials

    Harvard University – Cambridge, Massachusetts, United States

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