 | | Vol. 11.45 – 14 November, 2023 |
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| Researchers reported that patients with autosomal recessive NIK or RELB deficiency, or a specific type of autosomal-dominant NF-κB2 deficiency, also have neutralizing autoantibodies against type I interferons.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To deconstruct the cell states and pathways that characterized this pathogenic heterogeneity, scientists profiled the full spectrum of cells in inflamed synovium from patients with rheumatoid arthritis.
[Nature] |
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| Using single-cell RNA/T cell receptor/BCR-seq with protein feature barcoding, the authors profiled 317 samples from 166 healthy individuals aged 25–85 years old.
[Immunity] |
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| Scientists showed that deletion of ST2, the receptor for interleukin (IL)-33, on Treg cells increased granulocyte influx into the lung and increased cytokine production by innate lymphoid and γδ T cells without alteration of adaptive immunity to influenza.
[Nature Immunology] |
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| Researchers found that, in addition to triggering SIRPα, CD47 suppressed phagocytosis by a SIRPα-independent mechanism.
[Nature Immunology] |
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| By employing CD16 as a donor selection biomarker, investigators harnessed Vδ2 T cells characterized by heightened cytotoxicity and potent antibody-dependent cell-mediated cytotoxicity functionality.
[Nature Communications] |
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| The authors developed a suite of mathematical tools to search for statistically significant co-locations amongst immune and structural cells identified using 37-plex imaging mass cytometry.
[Nature Communications] |
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| Researchers employed deep immune profiling and T cell receptor sequencing and examined proliferation to assess how antiretroviral therapy impacted T cell homeostasis.
[Cell Reports Medicine] |
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| Scientists reported results from a multi-omic analysis of a large, real-world melanoma cohort. Melanoma brain metastases exhibited lower interferon-gamma scores and T cell-inflamed scores compared to primary cutaneous melanoma or extracranial metastases.
[npj Precision Oncology] |
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| Researchers used single-nuclei RNA sequencing to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening traumatic brain injury.
[Cell Reports] |
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| Investigators assessed the potential of an oncolytic adenovirus expressing a variant interleukin-2 (vIL-2) cytokine, Ad5/3-E2F-d24-vIL2, also known as TILT-452, to enhance NK cell therapy efficacy in human ovarian cancer ex vivo.
[Cancer Gene Therapy] |
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| Scientists comprehensively discuss the basis behind the tumoral dysregulation of cellular stress-immunity cycle.
[Immunological Reviews] |
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| Article-processing charges (APC) levied by publishers on authors have become an integral — and sometimes unpopular — part of the open-access revolution. Other options are being explored.
[Nature] |
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| November 18 – 19, 2023
Montréal, Québec, Canada |
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| | Chinese Academy of Sciences – Shenzhen, China |
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| | University of California – Los Angeles, California, United States |
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| | Masaryk University – Brno, Czech Republic |
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| | Armenian Bioinformatics Institute – Yerevan, Armenia |
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| | Cedars-Sinai – Los Angeles, California, United States |
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