Human Immunology News Volume 11.36 | Sep 12 2023

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    2023-09-12 | HIN 11.36


    Human Immunology News by STEMCELL Technologies
    Vol. 11.36 – 12 September, 2023
    TOP STORY

    Spatial Predictors of Immunotherapy Response in Triple-Negative Breast Cancer

    Researchers investigated the impact of multicellular spatial organization on response and explored how immune checkpoint blockade remodeled the tumor microenvironment.
    [Nature]

    Full Article
    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    PUBLICATIONSRanked by the impact factor of the journal

    Phosphoantigens Glue Butyrophilin 3A1 and 2A1 to Activate Vγ9Vδ2 T Cells

    Scientists showed how—in both humans and alpaca—multiple phosphoantigens functioned as ‘molecular glues’ to promote heteromeric association between the intracellular domains of BTN3A1 and the structurally similar butyrophilin BTN2A1.
    [Nature]

    Full Article

    CMTM6 Shapes Antitumor T Cell Response through Modulating Protein Expression of CD58 and PD-L1

    Using two systematic approaches, researchers revealed that CKLF like MARVEL transmembrane domain containing 6 (CMTM6) positively regulated CD58 expression.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity

    Using a novel enzymatic inhibitor of the RNA methyl­transferase METTL3, the authors demonstrated that a global decrease in N6-methyladenosine resulted in double-stranded RNA formation and a profound cell-intrinsic interferon response.
    [Cancer Discovery]

    AbstractPress Release

    Preexisting Tumor-Resident T Cells with Cytotoxic Potential Associate with Response to Neoadjuvant Anti–PD-1 in Head and Neck Cancer

    Investigators identified reinvigoration of cytotoxicity among ZNF683+CD8+ T cells as a likely mechanism underlying response to neoadjuvant anti–PD-1 in head and neck cancer.
    [Science Immunology]

    Abstract

    Exploiting a Rodent Cell Block for Intrinsic Resistance to HIV-1 Gene Expression in Human T Cells

    Researchers used precision CRISPR/Cas9 gene editing to engineer a “mousified” version of one such host protein, cyclin T1, in human T cells.
    [mBio]

    Full Article

    MAdCAM-1 Targeting Strategy Can Prevent Colitic Cancer Carcinogenesis and Progression via Suppression of Immune Cell Infiltration and Inflammatory Signals

    Scientists evaluated the expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), CD31, and immune cell markers in samples surgically resected from 11 ulcerative colitis patients with dysplasia/colitic cancer and 17 patients with sporadic colorectal cancer.
    [International Journal of Cancer]

    AbstractGraphical Abstract

    Highly Multiplexed Spatial Analysis Identifies Tissue-Resident Memory T Cells as Drivers of Ulcerative and Immune Checkpoint Inhibitor Induced Colitis

    Investigators showed that intra-epithelial CD8+ T cells were significantly more abundant in anti-PD-1 ± anti-CTLA-4-induced colitis compared to anti-CTLA-4-induced colitis and ulcerative colitis.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Prognostic and Immunological Roles of IL18RAP in Human Cancers

    The authors discovered that IL18 receptor accessory protein (IL18RAP) was related to the human tumor microenvironment and promotes various immune cell infiltration.
    [Aging]

    Full Article
    Daniel Grey investigates cell death modification as a potential therapy for immune disorders. View his profile.
    REVIEWS

    Targeting Innate Immune Pathways for Cancer Immunotherapy

    Scientists present a framework wherein distinct innate immune signaling pathways activate five key dendritic cell activities that are important for T cell-mediated immunity.
    [Immunity]

    Abstract
    INDUSTRY AND POLICY NEWS

    UK Finally Rejoins Horizon Europe Research Funding Scheme

    The UK government announced that it will rejoin the European Union’s €95 billion research funding program known as Horizon Europe.
    [ScienceInsider]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Laboratory Research Officer – Neural Circuits and Immunity in Psychosis

    Francis Crick Institute – London, England, United Kingdom

    Assistant Professor – Cancer, Cardiovascular and Metabolic Health, or Brain, Mind, and Behavior

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Fellow – Tumor Immunology

    National Cancer Institute – Bethesda, Maryland, United States

    Professorship – Immune Cell & Tissue Interactions

    University of Regensberg – Heidelberg, Germany

    Postdoctoral Scientist – Cancer Research Cluster

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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