Human Immunology News Volume 11.32 | Aug 15 2023

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    Laurisa Dohm
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    2023-08-15 | HIN 11.32


    Human Immunology News by STEMCELL Technologies
    Vol. 11.32 – 15 August, 2023
    TOP STORY

    Daratumumab Monotherapy for Refractory Lupus Nephritis

    Researchers reported a case series of six patients with a median age of 41.3 years with refractory lupus nephritis who received renal biopsies and were subsequently treated with intravenous daratumumab, an anti-CD38 monoclonal antibody.
    [Nature Medicine]

    Full Article
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
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    Human Microglia Maturation Is Underpinned by Specific Gene Regulatory Networks

    Scientists characterized stage-specific transcriptomes and epigenetic landscapes of fetal and postnatal human microglia and acquired corresponding data in induced pluripotent stem cell-derived microglia, in cerebral organoids, and following engraftment into humanized mice.
    [Immunity]

    Full ArticleGraphical Abstract

    Single-Cell Analysis of Human MAIT Cell Transcriptional, Functional and Clonal Diversity

    The authors analyzed the single-cell transcriptome and T cell receptor (TCR) repertoire of blood and liver MAIT cells, and developed functional RNA-sequencing, a method to integrate function and TCR clonotype at single-cell resolution.
    [Nature Immunology]

    Full Article

    Interleukin 4-Driven Reversal of Self-Reactive B Cell Anergy Contributes to the Pathogenesis of Systemic Lupus Erythematosus

    A combination of phenotypical, large-scale transcriptome, and B cell receptor repertoire profiling were employed at molecular and single cell level on samples from healthy donors and patients with systemic lupus erythematosus.
    [Annals Of The Rheumatic Diseases]

    Abstract

    High-Throughput Characterization of HLA-E-Presented CD94/NKG2x Ligands Reveals Peptides Which Modulate NK Cell Activation

    Utilizing sequences identified via yeast display selections, investigators trained prediction algorithms and identifed human and cytomegalovirus proteome-derived, human leukocyte antigen E (HLA-E)-presented peptides capable of binding and signaling through both CD94/NKG2A and CD94/NKG2C.
    [Nature Communications]

    Full Article

    Memory-Like Differentiation, Tumor Targeting Monoclonal Antibodies, and Chimeric Antigen Receptors Enhance Natural Killer Cell Responses to Head and Neck Cancer

    Researchers generated ML natural killer and conventional NK cells from healthy donors, then evaluated their ability to produce IFN-γ, TNF, degranulate, and kill head and neck squamous cell carcinoma (HNSCC) cell lines and primary HNSCC cells.
    [Clinical Cancer Research]

    Abstract

    XCR1 Expression Distinguishes Human Conventional Dendritic Cell Type 1 with Full Effector Functions from Their Immediate Precursors

    Investigators described that human conventional dendritic cells type 1 (cDC1) could be distinguished into XCR1− and XCR1+ cDC1 in lymphoid, as well as nonlymphoid, tissues.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers

    The authors reported that annexin 1 (ANXA1) knockdown dramatically downregulated PD-L1 expression in breast cancer, lung cancer, and melanoma cells.
    [Cancer Immunology Research]

    Abstract

    Superior Antibody Immunogenicity of a Viral-Vectored RH5 Blood-Stage Malaria Vaccine in Tanzanian Infants As Compared to Adults

    Scientists from the UK and Tanzania showed that the candidate vaccine ChAd63-MVA RH5 was safe in a Tanzanian phase Ib clinical trial, and immune responses were generated in participants living in a malaria-endemic setting.
    [Med]

    Full ArticleGraphical Abstract
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    REVIEWS

    Annals of the Rheumatic Diseases Collection on Autoantibodies in the Rheumatic Diseases: New Insights into Pathogenesis and the Development of Novel Biomarkers

    While autoantibodies have been investigated for over 50 years, recent studies have provided an exciting perspective on the mechanisms of autoantibody production and the power of new technologies to identify novel autoantibody targets to elucidate aetiology and underpin patient evaluation.
    [Annals Of The Rheumatic Diseases]

    Abstract

    Adenovirus-Mediated Combined Cytotoxic and Immune-Stimulatory Gene Therapy Using Dual-Vector Ad-hCMV-TK and Ad-hCMV-Flt3L: Translational Explorations from Rodents to Glioma Patients

    The authors provide a thorough overview of immune stimulatory gene therapy highlighting recent advancements, potential drawbacks, future directions, and recommendations for future implementation of clinical trials.
    [Molecular Therapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    India Creates New Research Funding Agency, but Doubts Linger

    India’s Parliament last has approved a new research funding agency aimed at boosting the nation’s scientific standing. But some analysts are skeptical that the Anusandhan National Research Foundation—which aims to inject some $6 billion into basic and applied research over five years—will have a major impact.
    [Science Insider]

    Editorial
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    JOB OPPORTUNITIES

    Postdoctoral Position – Engineering of iPSC-NK cells

    Technical University of Denmark – Kongens Lyngby, Denmark

    Postdoctoral Position – Modeling of the Tumor Microenvironment

    The University of Copenhagen – Copenhagen, Denmark

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    City of Hope – Duarte, California, United States

    Assistant Professor – Immunology

    Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

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