Human Immunology News Volume 10.40 | Oct 11 2022

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    2022-10-11 | HIN 10.40


    Human Immunology News by STEMCELL Technologies
    Vol. 10.40 – 11 October, 2022
    TOP STORY

    mTOR Inhibition Attenuates cTfh Cell Dysregulation and Chronic T Cell Activation in Multi-Lineage Immune Cytopenias

    Investigators longitudinally profiled T and B cell subsets and measured cytokines and chemokines before and after sirolimus treatment. 11 of the 12 patients with multi-lineage immune cytopenia who tolerated sirolimus were followed for a median duration of 17 months.
    [Blood]

    Abstract
    Register for Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies.
    PUBLICATIONSRanked by the impact factor of the journal

    Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy

    Under light irradiation, generated reactive oxygen species disrupted the cellular redox homeostasis to lead to cytoplasm leakage of damaged mitochondrial double-stranded DNA, which was the initiator of the STING signal.
    [ACS Nano]

    AbstractGraphical Abstract

    BATF Epigenetically and Transcriptionally Controls the Activation Program of Regulatory T Cells in Human Tumors

    Researchers showed that Treg cells in the tumor microenvironment (TME) of human lung cancers harbored a completely different open chromatin profile compared with CD8+ T cells, conventional CD4M+ T cells in the TME, and peripheral Treg cells.
    [Science Immunology]

    Abstract

    Evolution and Modulation of Antigen-Specific T Cell Responses in Melanoma Patients

    The frequency of anti-melanoma-associated antigen T cells distinguished melanoma patients from healthy and predicted metastatic recurrence from primary melanoma.
    [Nature Communications]

    Full Article

    Visualizing Inflammation with an M1 Macrophage Selective Probe via GLUT1 As the Gating Target

    Scientists reported a fluorescent probe, CDr17, which was selective for M1 macrophages over M2 or M0. The selective staining mechanism of CDr17 was explicated as Gating-Oriented Live-cell Distinction through overexpressed GLUT1 in M1 macrophages.
    [Nature Communications]

    Full Article

    Combination Nivolumab, CD137 Agonism, and Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes for Patients with Metastatic Melanoma

    Stage III/IV metastatic melanoma patients with unresectable disease who were anti-PD-1 treatment-naïve were enrolled. Tumor-infiltrating lymphocytes were generated in the presence of anti-4-1BB antibody in vitro and expanded for adoptive cell transfer
    [Clinical Cancer Research]

    Abstract

    Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule-Targeting with Eribulin

    The authors analyzed DNA variants from isolated carcinoma and sarcoma components to show that ovarian carcinosarcoma from 18 women was monoclonal.
    [Cancer Research]

    Abstract

    Tetraspanin-5–Mediated MHC Class I Clustering Is Required for Optimal CD8 T Cell Activation

    Scientists reported a molecular association between tetraspanin-5 and MHC I molecules that started in the endoplasmic reticulum and was maintained on the plasma membrane.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Multiple Centrosomes Enhance Migration and Immune Cell Effector Functions of Mature Dendritic Cells

    Researchers reported the emergence of extra centrosomes in leukocytes during immune activation. Upon antigen encounter, dendritic cells passed through incomplete mitosis and arrest in the subsequent G1 phase leading to tetraploid cells with accumulated centrosomes.
    [Journal of Cell Biology]

    Abstract

    CD59-Regulated Ras Compartmentalization Orchestrates Antitumor T Cell Immunity

    Investigators found that the typical membrane-bound complement regulatory protein CD59 was located intracellularly in T cells, and that the intracellular form was increased in the T cells of cancer patients.
    [Cancer Immunology Research]

    Abstract

    Engineering of Immune Checkpoints B7-H3 and CD155 Enhances Immune Compatibility of MHC-I−/− iPSCs for β Cell Replacement

    By profiling the relevant NK-activating ligands on iPSCs during in vitro differentiation into pancreatic β cells, researchers found that they express high levels of B7-H3 and CD155.
    [Cell Reports]

    AbstractFull ArticleGraphical Abstract
    Keep current with the latest in pulmonary cell research.
    REVIEWS

    Drugging p53 in Cancer: One Protein, Many Targets

    Small molecules that can either protect p53 from its negative regulators or restore the functionality of mutant p53 proteins are gaining interest, and drugs tailored to specific types of p53 mutants are emerging.
    [Nature Reviews Drug Discovery]

    Full Article

    Immune-Checkpoint Inhibitor Use in Patients with Cancer and Pre-Existing Autoimmune Diseases

    Evidence is accumulating with regard to the use of ICIs in this ‘at-risk’ population, with retrospective data suggesting that they have an acceptable safety profile, but that there is a risk of disease flare or other immune-related adverse events occurrence.
    [Nature Reviews Rheumatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Compass Therapeutics Announces Clinical Collaboration with Merck To Evaluate CTX-471 in Combination with KEYTRUDA® (Pembrolizumab)

    Compass Therapeutics, Inc. announced a clinical trial collaboration and supply agreement with Merck to evaluate the safety and efficacy of Compass’ CTX-471, a fully human monoclonal antibody in combination with Merck’s anti-PD-1 therapy KEYTRUDA®.
    [Compass Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    Angiotensin

    November 13 – 18, 2022
    Ventura, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Immunobiology of Blood Diseases

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Immunothrombosis

    Blood Centre of Wisconsin – Milwaukee, Wisconsin, United States

    Assistant Professor – Leukemia, Ovarian, Colorectal, and Lung Cancer

    CancerCare Manitoba Research Institute – Winnipeg, Manitoba, Canada

    Associate Director – Histocompatibility Laboratory

    University of Michigan – Ann Arbor, Michigan, United States

    Research Fellow – CAR T Cells from iPSCs

    Memorial Sloan Kettering Cancer Center – New York, New York, United States

    > See All Jobs

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