 | | Vol. 10.32 – 16 August, 2022 |
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| After developing protocols for expansion of single-cell lymphocyte cultures, the authors sequenced whole genomes from 717 normal naive and memory B and T cells and hematopoietic stem cells.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The safety, tolerability, and recommended Phase II dose of an individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA-based neoantigen vaccine in combination with nivolumab and ipilimumab were assessed in an ongoing Phase I/II study in patients with advanced metastatic solid tumors.
[Nature Medicine] |
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| Scientists showed that gorilla adenovirus vaccine targeting tumor neoepitopes enhanced responses to anti–programmed cell death protein 1 therapy by improving immunogenicity and antitumor efficacy.
[Science Translational Medicine] |
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| In five unrelated families, investigators described an immune dysregulation syndrome of recurrent bacterial infections, autoimmunity, systemic inflammation, B cell lymphoproliferation, and hypergammaglobulinemia.
[Science Immunology] |
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| The authors revealed that purinergic signaling in gliomas was shaped by genotype, lineage, and functional state, and that core enzymes expressed by tumor and myeloid cells were organized to promote adenosine-rich microenvironments potentially amenable to therapeutic targeting.
[Nature Communications] |
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| Researchers demonstrated the utility of structure-guided engineering of ligand-based binding domains with appropriate selectivity while validating IL13-mutein CARs with improved selectivity for application to systemic IL13Rα2-expressing malignancies.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors initially observed that CAR-T cells showed rapid differentiation and increased exhaustion after co-culture with tumor cells in vitro, and then performed single-cell ATAC-seq to depict the comprehensive and dynamic landscape of chromatin accessibility of CAR-T cells during tumor cell stimulation.
[Leukemia] |
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| Compared to primary tumors, liver metastases in both mice and humans were infiltrated by highly anergic T cells and MHCIIloIL10+ macrophages that were unable to present tumor-antigen.
[Oncogene] |
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| Investigators applied their recently developed digital-PCR assays to monitor CD19-CAR-T cell kinetics in cerebrospinal fluid and blood in real-world patients with neurotoxicity.
[Haematologica] |
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| Researchers engineered a cytokine-anchored CAR T cell system using a chimeric IL-5-CD28-CD3ζ receptor to trigger T cell-mediated killing of eosinophils that were elevated during severe asthma attacks.
[Cell Discovery] |
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| The antitumor activity and mechanism of action of IBI38D9-L were investigated in vitro using B cell non-Hodgkin lymphoma cell lines and human primary effector cells and in vivo using xenograft models reconstituted with human peripheral blood mononuclear cells.
[Cancer Immunology Immunotherapy] |
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| Scientists indicated that circulating human neutrophils were transcriptionally heterogeneous cells, which could be classified into one of four transcriptional clusters that were reproducible among healthy human subjects.
[Journal of Immunology] |
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| Researchers showed that IL1R1-signaling triggered enteric gliosis, which resulted in Muscularis Externa macrophage activation and the development of postoperative ileus.
[Communications Biology] |
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| The authors expand the discussion of three hypotheses on how certain factors can contribute to the differences and similarities between the loss of immune tolerance in children and the development of established immune-mediated arthritis in adults.
[Nature Reviews Rheumatology] |
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| Scientists review our current understanding of innate lymphoid cells in cancer with a particular focus on liver and liver-related diseases.
[Cellular & Molecular Immunology] |
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| Investigators discuss the environment where immune and beta cell interactions occur, the key cell types and molecules involved, and the outcomes of these interactions.
[Molecular Metabolism] |
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| Arbele, a clinical stage biopharmaceutical company, announced the successful dosing of the first patient in Australia in Phase I Study of ARB202, for the treatment of advanced gastrointestinal cancers patients.
[Arbele] |
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| Turns out NexImmune is not resistant to the tough competition in multiple myeloma. The company cited the competitive environment in the blood cancer space as reason for pausing enrollment on one of its two clinical candidates.
[Fierce Biotech] |
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| October 20 – 21, 2022
Turin, Italy |
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| | National Research Council Canada – Toronto, Ontario, Canada |
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| | Duke University – Durham, North Carolina, United States |
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| | University Hospital Cologne – Cologne, Germany |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | University of Illinois at Chicago – Chicago, Illinois, United States |
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