 | | Vol. 10.16 – 26 April, 2022 |
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| In a survey of T cells in mouse and human malignancies, researchers identified a population of αβ T cell receptor-positive FCER1G-expressing innate-like T cells with high cytotoxic potential.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Through cellular indexing of transcriptomes and epitopes by sequencing and TCR-sequencing of non-small cell lung cancer tumor-infiltrating lymphocytes, the authors developed a neoantigen-reactive T cell signature based on clonotype frequency and CD39 protein and CXCL13 mRNA expression.
[Cancer Cell] |
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| Scientists demonstrated the use of extracellular vesicles from red blood cells, which were highly amenable for RNA loading and taken up robustly by cancer cells, for RIG-I agonist delivery.
[Journal of Extracellular Vesicles] |
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| Researchers used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.
[Circulation Research] |
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| Transcription factor profiling identified increased KLF10 expression in hypertensive human subjects and in CD4+ T cells in Ang II-treated mice.
[Circulation Research] |
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| To overcome the challenges faced with CAR-T cells using donor-derived conventional CD4+ or CD8+ T cells, scientists evaluated the feasibility, safety, and efficacy of using healthy donor–derived allogeneic double-negative T cells as a CAR-T cell therapy platform.
[Science Immunology] |
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| Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.
[Nature Communications] |
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| The authors identified translationally controlled tumor protein (TCTP) as an immune-resistance factor that correlated with clinical outcome of anti-PD-L1 therapy and confered immune-refractory phenotypes and decreased T cell trafficking to the tumor.
[Nature Communications] |
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| Investigators analyzed the immune cell infiltrates of head and neck squamous cell carcinoma and colorectal cancers and identified a subset of CD4 T helper cells distinct from FOXP3+ regulatory T cells that co-expressed PD-1 and ICOS.
[Journal of Clinical Investigation] |
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| By using primary human DCs, scientists showed that hexagonal boron nitride, graphene oxide and molybdenum disulphide had minimal effects on the viability of primary human dendritic cells.
[Small] |
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| The authors evaluated serial blood samples from patients with epithelial ovarian cancer undergoing standard-of-care neoadjuvant carboplatin and paclitaxel chemotherapy to characterize the evolution of the peripheral immune cell function and composition during therapy.
[Clinical Cancer Research] |
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| Researchers reported an international study of fifty-five children and adolescents who received chimeric-antigen receptor (CAR) T cell therapy for relapsed B cell precursor acute lymphoblastic leukemia with CNS involvement at the time of referral.
[Leukemia] |
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| Investigators simultaneously quantified cytokine production and immunophenotype in human peripheral B cells across a range of stimulatory conditions and time points using mass cytometry.
[Cell Reports] |
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| Scientists discuss the goals of cellular immunotherapy in cancer, key challenges facing the field and exciting strategies that are emerging to overcome these obstacles.
[Nature Medicine] |
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| Investigators summarize the knowledge of cellular participants and key inflammatory signaling pathways in atherosclerosis and discuss the preclinical studies targeting these key pathways for atherosclerosis and the clinical trials that are going to target some of these processes.
[Signal Transduction and Targeted Therapy] |
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| The authors discuss the critical roles of four physical cues in solid tumors for regulating the immune responses of CAR-T cells, which include solid stress, fluid pressure, stiffness and microarchitecture.
[Advanced Drug Delivery Reviews] |
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| Portage Biotech, Inc. announced that it has entered a Cooperative Research and Development Agreement with the National Cancer Institute and Stimunity, S.A.S, an affiliate of Portage with experience in the preclinical development of stimulator of interferon genes agonists for cancer immunotherapy.
[Portage Biotech, Inc.] |
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| Regeneron Pharmaceuticals, Inc. and Checkmate Pharmaceuticals, Inc., a clinical stage biopharmaceutical company focused on proprietary technology to harness the power of the immune system to combat cancer, announced a definitive agreement for the acquisition of Checkmate by Regeneron.
[Regeneron Pharmaceuticals, Inc.] |
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| Autolus Therapeutics plc announced that the US FDA has granted RMAT designation to its lead gene therapy obecabatagene autoleucel (Obe-Cel), an autologous chimeric antigen receptor (CAR) T therapy that is being investigated in the FELIX Phase II study of adult B-acute lymphocytic leukemia (B-ALL).
[Autolus Therapeutics plc] |
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| ImmunityBio, Inc. announced that the first participants have been enrolled in a study that is part of an 800-site master protocol trial for non-small cell lung cancer.
[ImmunityBio, Inc.] |
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| June 1 – 4, 2022
Breckenridge, Colorado, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | University of California, San Diego – La Jolla, California, United States |
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| | Fred Hutchinson Cancer Center – Seattle, Washington, United States |
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| | City of Hope – Duarte, California, United States |
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| | University Hospital Carl Gustav Carus Dresden – Dresden, Germany |
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