 | | Vol. 10.04 – 1 February, 2022 |
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| Scientists investigated the cellular source for secreted anterior gradient-2 (AGR2) in the tumor microenvironment and underlying mechanisms mediating secreted AGR2’s effects.
[Gut] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.
[Science Advances] |
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| Researchers reported that the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) co-localized with programmed death ligand 1 (PD-L1) on the exosomes; both ICAM-1 and PD-L1 were upregulated by interferon-γ.
[Developmental Cell] |
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| Investigators tested the in vitro effect of different NK cell engagers, which triggered either NKp46 or NKp30 together with CD16A, and target either CD19 or CD20 to induce killing of pediatric B cell precursor acute lymphoblastic leukemia.
[Cancer Immunology Research] |
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| Using a defined engineered thymic niche system, the authors undertook a multi-stage statistical learning-based optimization campaign and identified IL-3 and tumor necrosis factor α as a stage- and dose-specific enhancers of cell proliferation and T-lineage differentiation.
[NPJ Regenerative Medicine] |
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| Researchers investigated the role of flagellin in promoting immunotherapy efficacy through modulating oxidative stress in regulatory B cells.
[Oxidative Medicine and Cellular Longevity] |
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| The authors constructed a pyroptosis-related gene signature in uveal melanoma patients. Patients from The Cancer Genome Atlas served as the training cohort, whereas patients from Gene Expression Omnibus served as the validation cohort.
[Scientific Reports] |
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| Scientists investigated whether chronic inflammation markers C-reactive protein and soluble urokinase-type plasminogen activator receptor, as well plasma levels of five different cytokine-specific autoantibodies.
[Scientific Reports] |
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| Leukocyte, platelet, neutrophil, and lymphocyte counts were assessed. Researchers analyzed the association of neutrophil-derived factors with clinical severity scoring systems.
[Scientific Reports] |
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| Investigators provide strategic guidance for the translation of novel targets of immunotherapy into improvements in patient outcomes.
[Nature Reviews Cardiology] |
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| The authors discuss the immunoregulatory functions of human LILRBs and the potential of targeting them to manipulate immune responses in various pathologies.
[JCI Insight] |
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| INmune Bio, Inc. announced that the company has entered into a pre-clinical research collaboration with Chinese University of Hong Kong to evaluate INKmune™ in nasopharyngeal cancer, a type of head and neck cancer.
[INmune Bio, Inc.] |
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| Immune-Onc Therapeutics, Inc. announced that the FDA cleared the company’s Investigational New Drug (IND) application for IO-202, a first-in-class antibody targeting leukocyte immunoglobulin-like receptor B4 (LILRB4) for the treatment of solid tumors.
[Immune-Onc Therapeutics, Inc.] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | Osaka University – Osaka, Japan |
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| | Flanders Institute for Biotechnology – Leuven, Belgium |
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| | Dalhousie University Faculty of Medicine – Halifax, Nova Scotia, Canada |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Oslo University Hospital – Oslo, Norway |
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