 | | Vol. 4.25 – 10 July, 2020 |
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| Scientists developed a strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells by first optimizing the specification of arterial and venous angioblasts and derivative endothelial populations.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that therapeutic targeting of methylation-controlled J protein (MCJ) in the liver with nanoparticle- and GalNAc-formulated siRNA efficiently reduced liver lipid accumulation and fibrosis in multiple non-alcoholic steatohepatitis mouse models.
[Nature Communications] |
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| Overexpression of RBM43 suppressed cell proliferation in culture and resulted in the growth arrest of tumor xenografts, whereas downregulating RBM43 played an opposite role.
[Oncogene] |
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| The recombinant adeno-associated virus vectors were used to hepatic-specifically inhibit SLC46A1 expression to observe its effects on hepatic iron metabolism. The abilities of SLC46A1 in importing heme and folate, and consequent alterations of iron content in hepatocytes were determined and effects of iron on SLC46A1 expression were investigated both in vitro and in vivo.
[Metabolism-Clinical and Experimental] |
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| Mac-2-binding protein (M2BPGi)-regulating signals in hepatocellular carcinoma (HCC) cells were investigated using transcriptome analysis. The effects of M2BPGi on HCC properties and galectin-3/mTOR signaling were evaluated.
[British Journal of Cancer] |
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| A coculture system and a subcutaneous xenograft model involving coimplantation of mouse hepatoma cells and primary activated hepatic stellate cells were used to study the effects of dexmedetomidine on hepatocellular carcinoma progression.
[Experimental and Molecular Medicine] |
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| Scientists observed that human Mpv17-like protein (M-LPH)-KO in HepG2 cells caused an increase in the level of mitochondrial cAMP and a reduction of total cellular cyclic nucleotide phosphodiesterase activity.
[Biochimica et Biophysica Acta-Molecular Cell Research] |
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| The authors found that propofol, a widely used anesthetic could prevent the proliferation by MTT assay. The scratch wound and invasion assays showed that migratory property and invasiveness in hepatocellular carcinoma cells SMMC-7721 was inhibited by propofol.
[Scientific Reports] |
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| Scientists showed ROCK2 to be a novel target of celastrol, and inhibition of ROCK2 suppressed elicited ezrin activation and liver cancer cell migration.
[Scientific Reports] |
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| Researchers showed that hepatic aldolase B suppresses hepatocellular carcinogenesis by directly binding and inhibiting the rate-limiting enzyme in the pentose phosphate pathway, glucose-6-phosphate dehydrogenase.
[Nature Cancer] |
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| Researchers summarize the central molecular machinery of ferroptosis, describe the role of ferroptosis in non-cancer hepatic disease conditions and discuss the potential to manipulate ferroptosis as a therapeutic strategy.
[Cell Death & Disease] |
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| Assembly Biosciences, Inc. have announced that the US FDA has granted Fast Track designation to ABI-H2158 (2158) for the treatment of patients with chronic hepatitis B infection. 2158 is Assembly’s second-generation core inhibitor, which is being evaluated in an ongoing global Phase II trial.
[Assembly Biosciences, Inc.] |
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| Enanta Pharmaceuticals, Inc., has announced advancements in its hepatitis B virus program evaluating EDP-514 across different patient populations.
[Enanta Pharmaceuticals, Inc.] |
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| International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT] |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Deep Genomics – Toronto, Ontario, Canada |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Yale University – New Haven, Connecticut, United States |
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| | Beam Therapeutics – Cambridge, Massachusetts, United States |
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