 | | Vol. 15.47 – 16 December, 2020 |
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| Investigators developed a machine learning approach to identify small molecules that broadly correct gene networks dysregulated in a human iPSC disease model of a common form of heart disease involving the aortic valve.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that embedding of ESC-derived aggregates in an extracellular matrix surrogate generated more advanced in vitro models that were formed in a process highly analogous to embryonic development.
[Science] |
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| After researchers filtered reads to remove sequences of mouse origin, the actual incidence of oncogenic polymorphisms arising in naive PSCs was close to zero.
[Cell Stem Cell] |
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| The authors established a microfluidic human embryo model from human PSCs, and the resulting structures exhibited molecular and cellular features resembling the progressive development of the early post-implantation human embryo.
[Nature Protocols] |
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| Scientists defined transcriptional consequences of reduced dosage of the congenital heart disease transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human iPSCs.
[Developmental Cell] |
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| Investigators showed that exposure of ESCs, which are the in vitro equivalents of epiblasts, to ESC-derived extracellular vesicles helped to maintain their stem cell properties even under culture conditions that would otherwise induce differentiation.
[Developmental Cell] |
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| The authors developed a scalable suspension agitation culture platform for differentiating human iPSC-microcarrier aggregates into functional red blood cells and have demonstrated scalability of the process starting with six well plates and finally demonstrating in 500 mL spinner flasks.
[Stem Cell Reports] |
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| To mechanistically study the miR-199a/214 cluster, scientists used 2D and 3D human ESC models of kidney development. After confirming expression in each model, they inhibited the miRNAs using lentivirally transduced miRNA sponges.
[Stem Cell Reports] |
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| Using an RNA-seq platform, researchers identified and validated the differential gene expression of five transcription factors that were associated with a remarkable increase in the number of iPSC colonies generated from a patient with Parkinson’s disease.
[Scientific Reports] |
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| The authors analyzed the expression patterns of the most comprehensive list to date of housekeeping genes during iPSC reprogramming of a mouse neural stem cell line, N31. Their results showed that housekeeping genes’ expression fluctuates significantly during the iPSC reprogramming.
[Scientific Reports] |
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| Scientists elucidated epigenetic modifications contributing to pluripotency of human induced pluripotent stem cells in response to 3D culture. Unlike 2D monolayer cultures, 3D cultured cells aggregated with each other to form ball‐like aggregates.
[Journal of Cellular Physiology] |
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| Investigators present a human PSC-derived model of hepatic steatosis, which overcomes inherent challenges of current models, and provides insights into the metabolic rewiring associated with steatosis.
[iScience] |
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| The authors provide a perspective on the status of in vitro inner ear models and guidance on how to improve their applicability in translational research. They highlight the generation of inner ear cell types from PSCs as a particularly promising focus of research.
[Cell Death & Differentiation] |
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| Investigators wanted to study how the near-weightless, microgravitational environment of the International Space Station affects building-block cells in the hope of understanding some of the secrets of how they grow, divide and form into tissues.
[The Washington Post] |
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| January 7 – 8, 2021
Virtual |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | National Institute of Arthritis and Musculoskeletal and Skin Diseases – Washington, DC, United States |
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| | Genentech, Inc. – South San Francisco, California, United States |
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| | Ncardia – Share Gosselies, Belgium |
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