 | | Vol. 5.25 – 13 July, 2020 |
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| Investigators developed a strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells by first optimizing the specification of arterial and venous angioblasts and derivative endothelial populations.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated human periventricular endothelial cells, using human pluripotent stem cell technology, and extensively characterized its molecular, cellular, and functional properties.
[Molecular Psychiatry] |
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| Primary human endothelial cells are exposed to controlled concentrations of polymer‐functionalized silica nanoparticles to induce lysosomal damage and achieve cytosolic delivery.
[Small] |
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| Micropattern traction microscopy was used to study a wide range of focal adhesion traction forces generated by bovine vascular smooth muscle cells and bovine aortic endothelial cells cultured on substrates of stiffness of 3.6, 6.7, 13.6, and 30 kPa.
[Acta Biomaterialia] |
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| Cancer-associated fibroblasts enhanced the distance and surface area of the invasive cancer mass whilst inhibiting vascular-like network formation. These processes correlated with the upregulation of hepatocyte growth factor, metallopeptidase inhibitor 1 and fibulin-5.
[British Journal of Cancer] |
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| Researchers found that vasculogenic mimicry (VM) was associated with the overall survival of non-small-cell lung cancer patients, and that thrombin expression was closely related to VM formation.
[Signal Transduction and Targeted Therapy] |
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| Scientists showed that the exposure to Prostaglandin E2 switched pericytes to a fast-migrating, loosely adhered phenotype that failed to intimately interact with endothelial cells.
[Scientific Reports] |
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| The doxorubicin (DOX) loaded ethylenediamine triacetic acid-iron oxide nanoparticles released DOX within four days with the capability of an accelerated release in acidic microenvironments.
[Scientific Reports] |
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| Scientists characterized glomerular endothelial cells from wild type and col4α5 knockout Alport syndrome mice, a hereditary disorder characterized by progressive renal failure.
[Scientific Reports] |
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| The authors review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19.
[Nature Medicine] |
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| Merck and Eisai announced that the FDA has issued a complete response letter regarding Merck’s and Eisai’s applications seeking accelerated approval of KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, for the first-line treatment of patients with unresectable hepatocellular carcinoma.
[Merck, Inc.] |
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| International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT News] |
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| A new US immigration policy, which threatens to revoke visas for certain international students if they are not taking in-person classes, is stirring panic and confusion and causing some universities to push back with lawsuits.
[Science] |
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| July 20 – July 22
Virtual |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| | Universitätsklinikum Bonn – Bonn, Germany |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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| | Queen’s University Belfast – Belfast, United Kingdom |
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| | The Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
