Endothelial Cell News Volume 1.30 | Oct 31 2016

TOP STORY

Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling

The authors used multicolored fluorescent fate-mapping models to track the behavior of blood endothelial cells during lymph node (LN) expansion upon inflammation and subsequent return to homeostasis. They found that expansion of the LN vasculature relied on the sequential assembly of endothelial cell proliferative units. [Immunity] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

MicroRNA-Based Therapy of Gata2-Deficient Vascular Disease

Endothelial GATA2 was functionally analyzed in human endothelial cells in vitro. Endogenous siRNA-mediated knockdown and lentiviral-based overexpression were applied to decipher capacity of GATA2 in regulating cell viability and capillary formation. [Circulation] Abstract

VEGF-B Gene Therapy Inhibits Doxorubicin-Induced Cardiotoxicity by Endothelial Protection

Investigators considered vascular endothelial growth factor-B (VEGF-B) as a candidate for prevention of DOX-induced cardiotoxicity and congestive heart failure. They administered an adeno-associated viral vector expressing VEGF-B or control vector to normal and tumor-bearing mice one week before doxorubicin (DOX) treatment. VEGF-B treatment completely inhibited the DOX-induced cardiac atrophy and whole-body wasting. [Proc Natl Acad Sci USA] Abstract

Store-Operated Calcium Entry-Activated Autophagy Protects EPC Proliferation via the CAMKK2-MTOR Pathway in Ox-LDL Exposure

The authors designed a study to explore the role and molecular mechanisms of store-operated calcium entry-activated autophagy in proliferation of endothelial progenitor cells under hypercholesterolemia. [Autophagy] Abstract

Syndecan-4 Controls Lymphatic Vasculature Remodeling During Embryonic Development

Investigators showed that abnormal flow sensing in lymphatic endothelial cells caused by Sdc4 or Pecam-1 deletion in mice results in impaired lymphatic vessel remodeling including abnormal valve morphogenesis. [Development] Abstract

Establishment of a Translational Endothelial Cell Model Using Directed Differentiation of Induced Pluripotent Stem Cells from Cynomolgus Monkey

Scientists present a non-human primate in vitro endothelial cell system using induced pluripotent stem cells from Cynomolgus monkey (Macaca fascicularis). [Sci Rep] Full Article

Specific Disruption of Lnk in Murine Endothelial Progenitor Cells Promotes Dermal Wound Healing via Enhanced Vasculogenesis, Activation of Myofibroblasts, and Suppression of Inflammatory Cell Recruitment

Scientists found that genetic targeting of the Lnk gene in endothelial progenitor cells dramatically enhances the vasculogenic potential including cell proliferation, migration, and tubule-like formation as well as accelerates in vivo wound healing, with a reduction in fibrotic tissue and improved neovascularization via significant suppression of inflammatory cell recruitment. [Stem Cell Res Ther] Full Article

Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells

Chemerin, a novel adipokine, plays a role in the inflammation status of vascular endothelial cells. Hypoxia causes endothelial-cell proliferation, migration, and angiogenesis. The authors aimed at evaluating the protein and mRNA expression of chemerin after exposure of human coronary artery endothelial cells to hypoxia. [PloS One] Full Article

Erythrocyte Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion

Researchers hypothesized that microparticles (MPs) from stored red blood cells would activate endothelial cells. MPs from aged murine packed red blood cells were isolated and used to treat confluent layers of cultured endothelial cells. [Shock] Abstract

Differential Expression of Endothelial Nutrient Transporters (MCT1 and GLUT1) in the Developing Eyes of Mice

Scientists used whole mount preparations of murine eyes to found that the hyaloid vascular system predominantly expressed glucose transporter 1 (GLUT1) in the endothelium, in contrast to the brain endothelium. [Exp Eye Res] Abstract

Discovery of Pan-VEGF Inhibitory Peptides Directed to the Extracellular Ligand-Binding Domains of the VEGF Receptors

Scientists showed the identification and characterization of small 6-mer peptides that target the extracellular ligand-binding domain of all three vascular endothelial growth factor receptors. These peptides specifically prevent the binding of VEGF family members to all three receptors and downstream signaling but do not affect other angiogenic receptor tyrosine kinases and their ligands. [Sci Adv] Abstract

Human Endothelial Cell Models in Biomaterial Research

The authors provide an overview of established endothelial cell (EC) models and possible selection criteria to enable researchers to determine the most reliable and relevant EC model to use. [Trends Biotechnol] Abstract

Modulating Putative Endothelial Progenitor Cells for the Treatment of Endothelial Dysfunction and Cardiovascular Complications in Diabetes

The authors discuss how diabetes induces a decrease in the number and function of different pro-angiogenic cell types generically designated as putative endothelial progenitor cells (EPC), which encompasses cells from myeloid origin that act in a paracrine fashion to promote angiogenesis and putative “true” EPC that contribute to endothelial replacement. [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Eisai’s LENVIMA^® (Lenvatinib) Nominated for Galien Foundation’s Best Pharmaceutical Product

Eisai Inc. announced that LENVIMA^® (lenvatinib), the company’s multiple receptor tyrosine kinase inhibitor, has been nominated for Best Pharmaceutical Product at the 10^th Annual Prix Galien USA Awards Ceremony. [Eisai Inc. (PR Newswire Association LLC.)] Press Release

Two Baylor College of Medicine Faculty Members Named to National Academy of Medicine

Dr. Malcolm Brenner, founding director of the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist Hospital, and Dr. Cheryl Walker, founding director of the Center for Precision Environmental Health at Baylor, both renowned leaders in their respective fields, were elected to membership in the National Academy of Medicine. [Baylor College of Medicine] Press Release

Scientific Challenges Loom for Canada’s Popular Prime Minister

Many in Canada’s science community say they are reserving judgement, waiting to see whether Trudeau can sustain his string of victories as he tackles some of country’s thorniest science-policy issues. [Nature News] Editorial

Review Finds Misconduct in Events Surrounding WHO Fetal Growth Study

For the first time in its 68-year history, the World Health Organization (WHO) has concluded that researchers are guilty of research misconduct. An independent review commissioned by WHO has found that “research ethics misconduct occurred” in a multimillion-dollar global study on fetal growth led by researchers at the University of Oxford in the United Kingdom. [ScienceInsider] Editorial

Two Major California Research Institutes Will Merge

One of the biggest nonprofit biomedical research outfits in the world is getting a new translational medicine research arm, aimed at speeding the conversion of basic research insights into novel medicines. Officials at the Scripps Research Institute announced that it will merge with the California Institute for Biomedical Research, which was launched in 2012 as a nonprofit version of a drug development company. [ScienceInsider] Editorial

To Save Money, NSF Requires University Cost-Sharing for Rotators

The National Science Foundation (NSF) has decided that universities should pay 10% of the salaries of faculty members working temporarily at the agency. NSF hopes the new policy will demonstrate its commitment to saving taxpayer dollars without alienating the academic community that it relies upon to stay on the cutting edge of basic science. [ScienceInsider] Editorial

NEW 2017 European Cancer Congress
January 27-30, 2017
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Senior Scientific Researcher – Molecular Oncology (Genentech)

Cell Biologist – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland)

Research Fellow – Vascular Regeneration and Angiogenesis (University of Edinburgh)

Postdoctoral Research Scientist – Effects of Radiation and Other Insults on Angiogenesis and the Blood Brain Barrier (Columbia University Center for Radiological Research)

Postdoctoral Research Associate – Cancer Research (Weill Cornell College of Medicine)

Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB)

Research Specialist/Technician – Cardiovascular Diseases (University of Illinois Chicago College of Medicine)

Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.)

Faculty Position – Tumor Immunology (Vanderbilt University Medical Center)

Postdoctoral Associate – Cancer Research (Thomas Jefferson University)

Postdoctoral Fellow – Extracellular Vesicle [Exosome] Research in Cancer (McGill University)

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