Dermal Cell News Volume 2.24 | Jul 4 2016

TOP STORY

IL-13 from Intraepithelial Lymphocytes Regulates Tissue Homeostasis and Protects against Carcinogenesis in the Skin

Scientists showed that intraepithelial lymphocytes (IELs) cross-communicate with epithelial cells (ECs) via the production of IL-13. Skin ECs were activated by IEL-derived IL-13, enabling a canonical EC stress response. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Overexpression of PRAS40^T246A in the Proliferative Compartment Suppresses mTORC1 Signaling, Keratinocyte Migration and Skin Tumor Development

In transgenic mice, proline-rich Akt substrate of 40 kDa (PRAS40)^T246A remained bound to raptor in keratinocytes even after treatment with TPA, consistent with reduced mTORC1 signaling and altered levels of cell cycle proteins. [J Invest Dermatol] Abstract

Accelerating Skin Wound Healing by M-CSF through Generating SSEA-1 and -3 Stem Cells in the Injured Sites

The authors evaluated the biological significance of M-CSF on skin wound healing. In an in vivo mouse skin excisional wound model, they found that SSEA-positive stem cells were present in wounded but not normal skin. [Sci Rep] Full Article

Vitamin D-Induced Up-Regulation of Human Keratinocyte Cathelicidin Anti-Microbial Peptide Expression Involves Retinoid X Receptor α

Scientists determined the expression of cathelicidin anti-microbial peptide (CAMP), vitamin D receptor, and the retinoid X receptor isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1,25D3-induced upregulation of CAMP. [Cell Tissue Res] Abstract

Granzyme B Inhibits Keratinocyte Migration by Disrupting Epidermal Growth Factor Receptor (EGFR)-Mediated Signaling

The authors investigated the effects of granzyme B (GzmB) on keratinocyte cell migration using HaCaT cell line. Using electric cell-substrate impedance sensing and scratch assays, they demonstrated that GzmB inhibits keratinocyte migration by interfering with the EGFR pathway. [Biol Chem] Abstract

Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-ĸB Pathways in HaCaT Cells

Investigators found that plantamajoside attenuated ultraviolet B (UVB)-and-glycer-advanced glycation end products–induced matrix metalloprotease 1 (MMP-1) expression in HaCaT and HDF cells and proinflammatory cytokines expression by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) activated by reactive oxygen species. [Photochem Photobiol] Abstract

SKIN CANCERS & DISORDERS

miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer

Depleting miR-214 or elevating miR-148b blocked the dissemination of melanoma or breast cancer cells, an effect that could be accentuated by dual alteration. Mechanistic investigations indicated that dual alteration suppressed passage of malignant cells through the blood vessel endothelium by reducing expression of the cell adhesion molecules ITGA5 and ALCAM. [Cancer Res] Abstract

Inhibitions of mTORC1 and 4EBP-1 Are Key Events Orchestrated by Rottlerin in SK-Mel-28 Cell Killing

Scientists searched for apoptotic, necrotic/necroptotic and autophagic traits in Rottlerin-exposed cells. Although SK-Mel-28 cells are both apoptosis and autophagy competent, Western blotting analysis, caspase activity assay, nuclear imaging and the effects of autophagy, apoptosis and necroptosis inhibitors indicated that Rottlerin cytotoxicity was due to none of the aforementioned death mechanisms. [Cancer Lett] Abstract

Pentoxifylline Inhibits WNT Signaling in β-Catenin^high Patient-Derived Melanoma Cell Populations

Using patient-derived melanoma cell populations, scientists investigated the influence of pentoxifylline on melanoma cells with either high or low expression of β-catenin. [PLoS One] Full Article

Vasoactive Intestinal Peptide Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells via CREB/MITF/Tyrosinase Signaling

Researchers showed that the melanin contents, tyrosinase activity, and gene expression of tyrosinase and microphthalmia-associated transcription factor (MITF) were significantly increased by treatment with vasoactive intestinal peptide in B16F10 mouse melanoma cells and the stimulatory melanogenic effect was further examined in human epidermal melanocytes. [Biochem Biophys Res Commun] Abstract

Pivotal MicroRNAs in Melanoma: A Mini-Review

The authors review several pivotal microRNAs that may contribute to melanoma by involvement in the processes of invasion, migration, and metastasis of melanoma cells. [Mol Diagn Ther] Abstract

Visit our reviews page to see a complete list of reviews in the dermal cell research field.

Santalis Pharmaceuticals Announces Positive Results from a Study Using 10% East Indian Sandalwood Oil (EISO) Serum Formulation for the Treatment of Mild-to-Moderate Plaque Psoriasis

Santalis Pharmaceuticals announced positive results from its single-center, open-label, efficacy and tolerability proof-of-concept study using a proprietary 10% EISO serum formulation for the treatment of mild-to-moderate plaque psoriasis. [Santalis Pharmaceuticals (Business Wire)] Press Release

BioPharmX Announces Positive Topline Phase IIa Clinical Trial Results for BPX-01 in Patients with Acne-Causing Bacteria

BioPharmX Corporation announced topline results from its Phase IIa safety study of BPX-01, a unique topical gel formulation of minocycline. [Biopharmx, Inc.] Press Release

NEW 16^th World Congress on Cancers of the Skin/ 12^th Congress of the European Association of Dermato-Oncology
August 31-September 3, 2016
Vienna, Austria

Visit our events page to see a complete list of events in the dermal cell community.

NEW Postdoctoral Research Position – Cytokine Research (Temple University Lewis Katz School of Medicine)

Postdoctoral Positions – Cell, Developmental & Cancer Biology (Oregon Health & Science University)

Postdoctoral Fellow – Tissue Regeneration (US Army Institute of Surgical Research)

PhD – Regulation of Keratinocyte Cell Death by Rho Family GTPases (University of Birmingham)

Research Associate – Stem Cells in the Epidermis (Imperial College London)

Cancer Scientists (Hamad bin Khalifa University)

Research Scientist – Hair Biophysics (L’Oreal)

Associate Professor/Professor – Dermatology (The University of Texas MD Anderson Cancer Center)

Scientist – Target Validation (Innate Pharma)

Postdoctoral Positions – Stem Cell Biology and Regenerative Medicine (University of Southern California)

Medical Science Liaison Associate – Skin Diseases (Biofrontera Inc.)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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