Cord Blood News Volume 7.07 | Feb 26 2015

Increased Expression of HIF2α during Iron Deficiency-Associated Megakaryocytic Differentiation
Researchers evaluated the megakaryocyte differentiation under iron deficiency in an in vitro model and investigated potential genes involved in this process. HEL, CMK, and cord blood-derived hematopoietic stem cells were cultured under iron deficiency. [J Thromb Haemost] Abstract

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse
Scientists generated a severe immunodeficient NOD/Shi-scid-IL-2Rγ^null (NOG) mouse substrain expressing the transgenic human IL-2 gene (NOG-IL-2 Tg). Upon transfer of human cord blood-derived hematopoietic stem cells, CD3^–CD56^highCD16^+/- cells developed unexpectedly, predominantly in the NOG-IL-2 Tg. [J Immunol] Abstract

Extensive Characterization of Platelet Gel Releasate from Cord Blood in Regenerative Medicine
Using a wide proteomic array and splitting the two components of the releasate, i.e. platelets and plasma, researchers have been able to study their growth factor content. They discovered high levels of hormones and molecules able to support tissue growth in the cord blood platelet gel releasate. [Cell Transplant] Full Article

The Notch Signaling Regulates CD105 Expression, Osteogenic Differentiation and Immunomodulation of Human Umbilical Cord Mesenchymal Stem Cells
To investigate the involvement of Notch signaling as well as other potential signaling pathway(s) in regulating multi-lineage differentiation and immunomodulatory functions of mesenchymal stem cells, scientists treated human umbilical cord-derived mesenchymal stem cells with γ-secretase inhibitor I, which inhibits both Notch signaling and ubiquitin-proteasome activities. [PLoS One] Full Article

Cord Blood Transplantation for Multiple Myeloma: Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation
Scientists evaluated the feasibility of cord blood transplantation (CBT) for patients with multiple myeloma. Eighty-six patients with multiple myeloma who underwent a first CBT between 2001 and 2011 were included in this retrospective study. [Biol Blood Marrow Transplant] Abstract

The Role of Toll-Like Receptor 3 and 4 in Regulating the Function of Mesenchymal Stem Cells Isolated from Umbilical Cord
The authors demonstrate that the activation of two toll-like receptors (TLRs), namely TLR3 and TLR4, in human umbilical cord-derived mesenchymal stem cells induces the expression of inflammatory markers. [Int J Mol Med] Abstract

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MD Anderson Joins CATCH^® Global Foundation to Boost Child Health, Prevent Cancer in Later Years
The University of Texas System Board of Regents approved the agreement that makes MD Anderson a founding partner in the foundation. Coordinated Approach to Child Health (CATCH^®) is a program developed and disseminated by The University of Texas Health Science Center at Houston School of Public Health. [The University of Texas MD Anderson Cancer Center] Press Release

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Principal Scientist – Hematopoietic Products (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

PhD Studentship – Stem Cells and Tissue Engineering (Queensland University of Technology)

Postdoctoral Scientist – Hematopoietic Stem Cell Transplantation (Indiana University)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Postdoctoral Fellow – Hematology and Oncology (Guangzhou Women and Children’s Medical Center)

Research Associate – Generating Mature Blood Cells from Induced Pluripotent Stem Cells (University of Cambridge)

Principal Investigator – Stem Cell Biology, Hematopoiesis and Hematology (Guangzhou Women and Children’s Medical Center)

PhD Studentships – Expansion of Umbilical Cord Blood Stem Cells (University College London)

Cord Tissue Processing Technician (Cord Blood Registry)

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