Cancer Stem Cell News Volume 5.04 | Feb 3 2016

Core Pathway Mutations Induce De-Differentiation of Murine Astrocytes into Glioblastoma Stem Cells that Are Sensitive to Radiation but Resistant to Temozolomide
To model genetic alterations in human glioblastomas core signaling pathways, researchers induced Rb knockout, Kras activation, and Pten deletion mutations in cortical murine astrocytes. [Neuro Oncol] Abstract

A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche
The authors used polymer microarrays for the rapid and efficient identification of glioma cancer stem cells niche mimicries and identified a urethane-based synthetic polymer, upon which two groups of niche components, namely extracellular matrices and iron were revealed. [Stem Cells] Abstract

Ki-67 Is Required for Maintenance of Cancer Stem Cells but Not Cell Proliferation
Researchers demonstrated that genetic disruption of Ki-67 in human epithelial breast and colon cancer cells depletes the cancer stem cell niche. Ki-67 null cells had a proliferative disadvantage compared to wildtype controls in colony formation assays and displayed increased sensitivity to various chemotherapies. [Oncotarget] Full Article 

IL-32θ Inhibits Stemness and Epithelial-Mesenchymal Transition of Cancer Stem Cells via the STAT3 Pathway in Colon Cancer
Ectopic expression of interleukin (IL)-32θ attenuated invasion, migration in vitro and in vivo tumorigenicity of colon cancer cells. IL-32θ inhibited epithelial-mesenchymal transition, resulting in the suppression of their migratory and invasive capabilities of HT29 colon cancer cells. [Oncotarget] Full Article

Development of Liposomal Formulation for Delivering Anticancer Drug to Breast Cancer Stem Cell-Like Cells and Its Pharmacokinetics in an Animal Model
The objective of the present study was to develop a liposomal formulation for delivering anticancer drug to breast cancer stem cell-like cells, ANV-1, and evaluate its pharmacokinetics in an animal model. [Mol Pharm] Abstract

Investigating the Radioresistant Properties of Lung Cancer Stem Cells in the Context of the Tumor Microenvironment
Investigators utilized a three-dimensional non-small cell lung cancer model, which had characteristics of the tumor microenvironment and tumor cell heterogeneity, to elucidate the multifactorial nature of radioresistance in tumors. [Radiat Res] Abstract

A1E Reduces Stemness and Self-Renewal in HPV 16-Positive Cervical Cancer Stem Cells
The authors investigated whether A1E can regulate epithelial-to-mesenchymal transition (EMT), cancer stem cells self-renewal, and stemness-related gene expression in cervical cancer cells. Down regulation of cell migration, cell invasion, and EMT was observed in A1E-treated SiHa cells. [BMC Complement Altern Med] Full Article

Mitochondrial Oligomers Boost Glycolysis in Cancer Stem Cells to Facilitate Blebbishield-Mediated Transformation after Apoptosis
Scientists demonstrated that N-Myc and VEGFR2 control transformation from blebbishields, during which oligomers of K-Ras, p27, BAD, Bax, and Bak boost glycolysis to avoid secondary necrosis. [Cell Death Discov] Full Article

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NEUMANN Diagnostics’ Automated Cervical Cancer Test Achieves Exceptional Accuracy
Molecular assays developer NEUMANN Diagnostics Ltd. unveiled its CONFIDENCE™ molecular test portfolio setting a new standard in cervical cancer screening. The tests demonstrated superior accuracy achieving very high sensitivity without compromising on specificity. [Neumann Diagnostics Ltd.] Press Release

TapImmune Granted Fast Track Designation by U.S. Food & Drug Administration for its Lead Vaccine TPIV 200 in the Treatment of Ovarian Cancer
TapImmune, Inc. announced that the United States Food & Drug Administration has granted Fast Track Designation for its cancer vaccine TPIV 200 in the treatment of ovarian cancer. [TapImmune] Press Release

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NEW Director Manufacturing – Cell and Gene Therapy (Fred Hutchinson Cancer Research Center)

NEW Lab Technician – Hematopoietic Stem Cell Biology (Fred Hutchinson Cancer Research Center)

NEW Research Assistant – Breast Cancer Biology (National University of Ireland Galway)

Post-Doc Fellowships – Integrative Analysis in Prostate and Breast Cancer (Baylor College of Medicine)

Research Scientist – Hematopoietic Stem Cell Transplantation (University of Chicago)

Staff Scientist – Cell Therapy Process Development (Fred Hutchinson Cancer Research Center)

Post-Doc Fellowship – Bioinformatics RNA Biology and Cancer (German Cancer Research Center)

Post-Doc Fellowship – Genetics and Genomics of Stem Cells (Albert Einstein College of Medicine of Yeshiva University)

Tenure Track Professorship – Tumor Biology and Signal Transduction (University Medical Center Gottingen)

Professor – Cancer Immunotherapy (Stanford Cancer Institute)

Postdoctoral Fellow – Cell and Molecular Biology of Leukemia (Virginia Commonwealth University)

Postdoctoral Fellow – Cancer Stem Cell Biology (Cleveland Clinic)

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